Objective To investigate the changes of serum PTX3 and UA levels in patients with severe preeclampsia(SPE)and their effects on maternal and infant outcomes.Methods Forty five SPE patients in our hospital from January 2020 to March 2021 were selected as SPE group,another PE patient in the same period was selected as PE group,and 45 healthy pregnant women were selected as control group.Serum PTX3,UA levels,systolic blood pressure(SBP),diastolic blood pressure(DBP)in three groups were compared.The correlation between serum PTX3,UA levels and SBP,DBP in SPE patients was analyzed,and the maternal and infant outcomes of patients with different serum PTX3,UA levels in SPE group were compared.Results The levels of PTX3,UA,SBP and DBP in SPE group were higher than those in PE group,and both groups were higher than those in control group(P＜0.05);Serum PTX3 and UA levels in SPE patients were positively correlated with SBP and DBP(P＜0.05);The incidence of adverse maternal and infant outcomes in patients with high ex-pression of serum PTX3 and UA in SPE group(69.23％,68.00％)was significantly higher than that in patients with low ex-pression of serum PTX3 and UA(31.58％,35.00％)(P＜0.05).Conclusion The levels of PTX3 and UA in serum of SPE patients are obviously high expression,and their expressions are positively correlated with the blood pressure(SBP,DBP)of SPE patients.Higher levels of PTX3 and UA in serum can increase the incidence of adverse outcomes of mothers and infants.
关键词
重度子痫前期/正五聚体蛋白3/尿酸/母婴结局
Key words
Severe preeclampsia/Pentamer protein 3/Uric acid/Maternal and infant outcomes
维普
万方数据