Objective To investigate the effects of different doses of mifepristone on tumor volume,serum hormones and hemorheology in patients with uterine fibroids.Methods A total of 113 patients with uterine fibroids admitted to our hospi-tal from February 2019 to February 2021 were selected and divided into a control group(n=55)and an observation group(n=58)according to the random number table.Both groups were given mifepristone on the basis of conventional treatment.The control group was treated with high-dose mifepristone(25 mg)for uterine fibroids,and the observation group was treated with low-dose mifepristone(12 mg)for uterine fibroids.The changes of uterine fibroid volume,serum hormone progesterone(P)level,estrogen(E2),luteinizing hormone(LH),follicle stimulating hormone(FSH),hemorheology and adverse reac-tions before and after 2 months of treatment were compared between the two groups.Results After treatment,the volume of hysteromyoma in the observation group was smaller than that in the control group,and the observation group had lower serum hormone levels of P,E2,LH and FSH than the control group(P＜0.05).After treatment,the observation group had lower hemodynamic indexes of high blood viscosity,low blood viscosity and platelet aggregation than the control group(P＜0.05).Compared with the control group,the observation group had lower total incidence of adverse reactions(P＜0.05).Conclusion Different doses of mifepristone can be used in the treatment of hysteromyoma,but the treatment of low-dose mifepristone is more significant in reducing serum hormone level and hemodynamic value,and the treatment safety is better.
关键词
米非司酮/子宫肌瘤患者/子宫肌瘤体积/血清激素/血液流变学
Key words
Mifepristone/Patients with uterine fibroids/Volume of uterine fibroids/Serum hormones/Hemorheology
维普
万方数据