辽宁医学杂志2024,Vol.38Issue(1) :73-76.

熄风定颤汤联合多潘立酮对帕金森患者认知功能、神经递质水平的影响

Effects of Xifeng dingzhan decoction combined with domperidone on cognitive function and neuro-transmitter levels in patients with Parkinson's disease

高崇 李志
辽宁医学杂志2024,Vol.38Issue(1) :73-76.

熄风定颤汤联合多潘立酮对帕金森患者认知功能、神经递质水平的影响

Effects of Xifeng dingzhan decoction combined with domperidone on cognitive function and neuro-transmitter levels in patients with Parkinson's disease

高崇 1李志2
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作者信息

  • 1. 社旗县中医院(河南南阳 473300)
  • 2. 社旗县人民医院(河南南阳 473300)
  • 折叠

摘要

目的 分析熄风定颤汤联合多潘立酮治疗帕金森的疗效及对患者认知功能、神经递质水平的影响.方法 将2020年1月~2022年1月我院收治的帕金森患者158例纳入研究对象的,以完全随机数法将其分为西药治疗组73例采用多潘立酮治疗、联合中药组85例采用熄风定颤汤联合多潘立酮治疗,于治疗前、治疗后观察两组研究对象指标变化.结果 与西药治疗组相比,联合中药组炎症因子水平、UPDRS评分、中医症候积分较低(P<0.05);MoCA评分、ADL评分、神经递质、治疗总有效率较高(P<0.05).结论 熄风定颤汤联合多潘立酮可抑制炎症状态、提升认知功能、改善神经递质水平,值得临床推广应用.

Abstract

Objective Analysis of the therapeutic effect of pralidone and pralidone on cognitive function of patients with Parkinson's disease.Methods 158 patients with Parkinson's disease treated in our hospital from January 2020 to January 2022 were included in the study.They were divided into 73 cases in the western medicine treatment group and 85 cases in the combined traditional Chinese medicine group.They were treated with Xifeng dingzhan Decoction and domperidone.The changes of the indexes of the two groups were observed before and after treatment.Results Compared with the western medicine treatment group,the level of inflammatory factors,UPDRS score and TCM syndrome score in the combined tradi-tional Chinese medicine group were lower(P<0.05);MOCA score,ADL score,neurotransmitter and total effective rate were higher(P<0.05).Conclusion Xifeng dingzhan decoction combined with domperidone can inhibit inflammatory state,improve cognitive function and improve neurotransmitter level,which is worthy of clinical application.

关键词

熄风定颤汤/多潘立酮/帕金森/认知功能/神经递质

Key words

Xifeng dingzhan Decoction/Domperidone/Parkinson's disease/Cognitive function/Neurotransmitter

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出版年

2024
辽宁医学杂志
辽宁省医学会

辽宁医学杂志

影响因子:0.339
ISSN:1001-1722
参考文献量18
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