摘要
目的 探究加味柴胡龙牡汤治疗脑卒中的临床疗效分析.方法 采用回顾性分析将本院2019年3月到2021年3月的73例患者分为观察组(n=40)与对照组(n=33),对照组使用常规治疗方法,观察组则在此基础上使用加味柴胡龙牡汤.观察两组的血液流变指标、神经功能缺损评分、临床疗效对比、抑郁状态评分、脑血流灌注指标与血清炎症因子变化.结果 观察组总有效率(92.50％)与对照组总有效率(93.93％)无统计学差异(x2=0.058,P=0.808).2组治疗后,观察组的神经功能损伤状态评分显著低于对照组(P＜0.05).治疗前2组患者的生活能力评分无统计学差异(P＞0.05).治疗后,观察组的生活能力评分显著高于对照组(P＜0.05).两组患者治疗前MTT、TTP、CBV、CBF指标无统计学差异(P＞0.05).治疗后观察组MTT、TTP指标较对照组显著降低,且CBV、CBF指标较对照组显著升高(P＜0.05).两组患者治疗前IL-6、TNF-α、hsCRP水平无统计学差异(P＞0.05).治疗后观察组IL-6、TNF-α、hsCRP水平较对照组显著降低(P＜0.05).治疗后,观察组的不良反应发生率(95.00％)略微高于对照组(93.94％),但不具有统计学差异(x2=0.039,P=0.842).
Abstract
Objective To investigate clinical efficacy of modified Chaihu Longmu decoction in treating stroke.Methods Seventy-three patients with stroke in our hospital from March 2019 to March 2021 were retrospectively classified into two groups.Control group(n=33)received routine treatment,based on this,observation group(n=40)received modified Chaihu Longmu decoction.Hemorheological indexes,neurological deficit score,clinical efficacy,depression score,cerebral blood flow perfusion index and serum inflammatory factors were compared between the two groups.Results The total efficacy rate was 92.50％in observation group,which presented no significant difference with 93.93％in control group(x2=0.058,P=0.808).The neurological deficit score demonstrated no significant difference between the two groups at the baseline(P＞0.05),and the post-treatment score was significantly lower in observation group than in control group(P＜0.05).The score of activity of daily living yielded no significant difference between the two groups at the baseline(P＞0.05),and observation group scored notably higher than control group after treatment(P＜0.05).Parameters including mean transit time(MTT),time to peak(TTP),cerebral blood volume(CBV)and cerebral blood flow(CBF)showed no statistical difference between two groups before treatment(P＞0.05),while observation group had obviously shorter MTT and TTP as well as larger CBV and CBF than those of control group,with statistical difference(all P＜0.05).Serum levels of interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and high-sensitivity CRP(hsCRP)presented no statistical difference between two groups before treatment(P＞0.05),and the three inflammation factors were remarkably decreased in observation group compared with control group after treatment(P＜0.05).The adverse reaction rate was 95.00％in observation group,which was slightly higher than 93.94％in control group,with no statistical difference(x2=0.039,P=0.842).Conclusion Modified Chaihu Longmu decoction in effective for stroke patients.
维普
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