α-SMA和肺泡灌洗液细胞因子水平在重症肺炎中检测意义
Correlation Between Cytokine Levels in Bronchoalveolar Fluid and Prognosis of α-SMA in Pa-tients with Severe Pneumonia
党照康1
作者信息
- 1. 郑州市金水区总医院(河南郑州 450000)
- 折叠
摘要
目的 探究肺泡灌洗液细胞因子水平及α-SMA在重症肺炎患者中的表达.方法 选取2017年5月至2018年10月我院重症医学科收治的重症肺炎患者92例作为研究对象,根据病程第10d临床转归情况,分为好转组55例与恶化组37例,在病程第1、5、10d,检查血清和肺泡灌洗液中细胞因子、α-SMA水平.结果 随着时间推移,好转组肺泡灌洗液各项细胞因子水平、α-SMA水平逐渐降低,恶化组逐渐升高;在第5d和第10d,好转组肺泡灌洗液各项细胞因子水平、α-SMA水平均明显低于恶化组,差异均具有统计学意义(P＜0.05).结论 肺泡灌洗液细胞因子水平及α-SMA水平可有效反映重症肺炎患者预后情况,肺泡灌洗液细胞因子水平及α-SMA水平升高,表示预后不良.
Abstract
Objective To explore the level of cytokines in alveolar lavage fluid and the expression of α-SMA in pa-tients with severe pneumonia.Methods A total of 92 patients with severe pneumonia admitted to the Department of Respir-atory Medicine from May 2017 to October 2018 were enrolled.According to the clinical outcome of the 10th day of the dis-ease,55 patients were classified into the improved group and 37 patients in the deterioration group.On the 1st,5th and 10th day of the disease,the levels of cytokines and α-SMA in serum and alveolar lavage fluid were examined.Results The cyto-kines levels in the BALF and α-SMA of the improved group gradually decreased over time,while those were gradually in-creased in the deterioration group(P＜0.05).On the 5 th day and the 10th day,the cytokine levels in the BALF and α-SMA levels of the improved group were significantly lower than those of the deterioration group(P＜0.05).Conclusion The cy-tokines levels in BALF and α-SMA can effectively reflect the prognosis of patients with severe pneumonia,in which its in-crease indicates poor prognosis.
关键词
肺泡灌洗液/细胞因子/α-SMA/重症肺炎Key words
Bronchoalveolar Fluid/Cytokines/α-SMA/Severe pneumonia引用本文复制引用
出版年
2024
NETL
NSTL
万方数据