Objective To observe the clinical characteristics of peripheral blood lymphocyte subset counts and percent-ages in patients with novel coronavirus infection(COVID-19).Methods The basic data of 77 patients with COVID-19 ad-mitted to Taizhou City Hospital of Traditional Chinese Medicine were retrospectively analyzed,the included cases were grouped by treatment protocol,the peripheral blood lymphocyte subsets of each group were analyzed and compared,and the relationship between blood oxygen saturation level and CD4/CD8 ratio was assessed using Pearson correlation analysis.Re-sults The 77 patients diagnosed included 26 light,39 medium,7 heavy,and 5 critical.Compared with light and medium,peripheral blood CD3+T-cell,CD4+T-cell,CD8+T-cell,B-cell,and NK-cell counts were significantly lower in heavy and critical patients;whereas the percentage of CD8+T-cells was significantly higher.The peripheral blood CD4/CD8 ratio was higher in patients in the severe and critical groups than in medium and light patients;there was a negative correlation between blood oxygen saturation levels and CD4/CD8 ratio in patients with COVID-19 infection.Conclusion Peripheral blood lymphocyte counts were significantly decreased in patients with COVID-19,especially in the heavy and critical groups,and the CD4/CD8 ratio may be a valid indicator to assess the severity of the disease in patients with COVID-19.
关键词
新型冠状病毒/外周血淋巴细胞亚群/CD4/CD8比值
Key words
COVID-19/Peripheral blood lymphocyte subsets/CD4/CD8 ratio
维普
万方数据