Objective To investigate the effects of dapagliflozin combined with metformin and acarbose on islet func-tion,glucose and lipid metabolism,and oxidative stress in patients with type 2 diabetes mellitus(T2DM).Methods A total of 58 patients with T2DM admitted to our hospital from October 2020 to October 2021 were selected and randomly divided into the observation group and the control group,with 29 cases in each group.Patients in the observation group were treated with dapagliflozin combined with metformin and acarbose,and those in the control group were treated with metformin com-bined with acarbose.The changes of islet function,glucose and lipid metabolism,and oxidative stress levels before and after treatment were compared between the two groups.Results After treatment,FINS and HOMA-IR in islet function indicators were decreased in both groups,and FINS(7.13±1.24)mU/L and HOMA-IR(2.24±0.59)in the observation group were lower than those[FINS(9.55±1.44)mU/L and HOMA-IR(3.18±0.74)]in the control group after treatment(P＜0.05).After treatment,FPG and 2hPG in glucose and lipid metabolism indicators and TG and TC in blood lipid indicators were decreased in both groups,and after treatment,the blood glucose indicators FPG(5.75±1.04)mmol/L,2hPG(8.18±1.45)mmol/L and blood lipid indicators TG(1.31±0.33)mmol/L,TC(3.99±0.91)mmol/L in the observation group were lower than those in the control group[(7.48±1.47)mmol/L,(10.11±1.59)mmol/L and(1.78±0.47)mmol/L,(4.75±1.01)mmol/L](P＜0.05).After treatment,the oxidative product content MDA decreased and the antioxidant en-zyme content SOD increased in the oxidative stress indicators of the two groups,and the MDA(8.01±1.64)nmol/mL in the observation group was lower than that in the control group[(10.38±2.43)nmol/mL],but SOD(95.33±10.49)U/L was higher than in the control group[(82.74±11.58)U/L](P＜0.05).Conclusion Dapagliflozin combined with met-formin and acarbose can effectively regulate islet function,reduce blood glucose and blood lipid levels and reduce oxidative stress in patients with type 2 diabetes mellitus.It is worth popularizing.
关键词
达格列净/二甲双胍/阿卡波糖/2型糖尿病/胰岛功能/糖脂代谢/氧化应激
Key words
Dapagliflozin/Metformin/Acarbose/Type 2 Diabetes Mellitus/Islet Function/Glucose and Lipid Metabo-lism/Oxidative Stress
维普
万方数据