Effect of continuous lumbar cisterna drainage combined with intrathecal injection of tegacycline on intracranial infection of Pandrug-resistant Acinetobacter baumannii and its influence on cere-brospinal fluid indexes
Effect of continuous lumbar cisterna drainage combined with intrathecal injection of tegacycline on intracranial infection of Pandrug-resistant Acinetobacter baumannii and its influence on cere-brospinal fluid indexes
Objective To investigate the effect of continuous lumbar cistema drainage combined with intrathecal injec-tion of tegacycline on intracranial infection caused by pan-drug resistant Acinetobacter baumannii.Methods Eighty-seven patients with intracranial infection of pandrug-resistant Acinetobacter baumannii in our department were selected and grouped according to the lottery method.Forty-three patients in the control group were treated with traditional intravenous antibiotics combined with intermittent intrathecal injection of antibiotics,while 44 patients in the observation group were treated with intravenous antibiotics combined with continuous lumbar cistema drainage combined with intrathecal injection of tigacycline.Results There was no statistical significance in 28d mortality between the two groups(P＞0.05).The duration of meningeal stimulation relief,temperature recovery and intracranial hypertension relief in the observation group were shor-ter than those in the control group.The number of nucleated cells,percentage of neutrophil and protein level in cerebrospinal fluid were lower than those in the control group,while the glucose level was higher.The number of white blood cells,C-reac-tive protein,percentage of neutrophil and raw calcitonin in blood were lower than those in the control group on average.There was statistical significance(P＜0.05).Conclusion Continuous lumbar cisterna drainage combined with intrathecal injection of tegacycline can effectively shorten the duration of clinical symptom relief,regulate cerebrospinal fluid indexes,and reduce mortality and inflammation in patients with pan-drug-resistant Acinetobacter baumannii intracranial infection.
维普
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