Effects of Loplatin neoadjuvant sequential concurrent chemoradiotherapy on tumor marker lev-els,serum CD105 and cell growth factors in patients with locally advanced cervical cancer
Effects of Loplatin neoadjuvant sequential concurrent chemoradiotherapy on tumor marker lev-els,serum CD105 and cell growth factors in patients with locally advanced cervical cancer
Objective To investigate the effect of loplatin neoadjuvant sequential concurrent chemoradiotherapy in pa-tients with locally advanced cervical cancer.Methods 104 patients with locally advanced cervical cancer in our department were selected and grouped by random number table.Fifty-two patients in the control group received cisplatin neoadjuvant se-quential chemoradiotherapy,and 52 patients in the observation group received loplatin neoadjuvant sequential chemoradio-therapy.Clinical control rate,tumor marker levels,serum cytokines and toxic and side effects were compared between the two groups.Results There was no statistical significance in SCC,CEA,CYFRA21-1 level,clinical control rate and incidence of toxic and side effects in 2 groups after treatment(P＞0.05).After treatment,the levels of CD105,VEGF and bFGF in the observation group were lower than those in the control group,with statistical significance(P＜0.05).Conclusion Cisplatin and Loplatin neoadjuvant sequential synchronous chemoradiotherapy have similar clinical efficacy and high safety in the treatment of locally advanced cervical cancer patients,but loplatin neoadjuvant sequential synchronous chemoradiotherapy can effectively regulate the levels of CD105 and microvascular cytokines.
关键词
顺铂新辅助放化疗/洛铂新辅助放化疗/子宫颈癌
Key words
Cisplatin neoadjuvant chemoradiotherapy/Loplatin neoadjuvant chemoradiotherapy/Cervical cancer
维普
万方数据