Analysis of the disease burden of moderate visual impairment caused by retinopathy in premature infants worldwide based on the GBD database
李军林1
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作者信息
1. 泗阳朝聚眼科医院(江苏宿迁 223799)
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摘要
目的 分析1990-2019年全球0～19岁儿童青少年早产儿视网膜病变(Retinopathy of Prematurity,ROP)致中度视力损伤(moderate vision loss,MVI)疾病负担的变化趋势,了解疾病负担现状,为ROP致盲的防控提供参考.方法 数据来源于全球疾病负担研究数据库(GBD2019),按照不同性别、年龄分析ROP相关MVI的患病率和伤残损失寿命年(YLD),评价疾病负担的变化情况.结果 1990-2019年全球0～19岁儿童青少年ROP相关MVI患病人数从70.6万人增加到95.1万人,增加35％,患病率由29.8/10万增加至35/10万(年度平均变化百分比,AAPC=0.59;95％CI:0.58 to 0.61).YLD 标化率由 0.9/10 万人年增加至 1.1/10 万人年(AAPC=0.6;95％CI:0.58 to 0.61);在患病率和YLD标化率方面,女性和男性均呈上升趋势,且女性上升趋势大于男性(AAPC=0.62 vs 0.56).结论 全球ROP所致MVI的患病和负担仍呈上升趋势,其防控工作仍面临巨大挑战,应加强筛查和提高治疗水平,尤其是5岁以下新生儿的防控工作,降低儿童青少年ROP相关MVI的疾病负担.
Abstract
Objective To analyze the changing trend of the disease burden of moderate vision loss(MVI)caused by ret-inopathy of prematurity(ROP)in children and adolescents aged 0-19 years worldwide from 1990 to 2019,understand the current situation of the disease burden,and provide reference for the prevention and control of blindness caused by retinopa-thy of prematurity.Methods The data is sourced from the Global Burden of Disease(GBD 2019),and the incidence of moderate visual impairment caused by retinopathy in premature infants and Years of Life with Disability(YLD)are analyzed by gender and age to evaluate the changes in disease burden.Results From 1990 to 2019,the global prevalence of ROP related MVI in children and adolescents aged 0-19 increased from 706000 to 951000,an increase of 35％,and the preva-lence rate increased from 29.8/100000 to 35/100000(AAPC=0.59;95％CI:0.58 to 0.61).The standardized rate of YLD increased from 0.9/100000 person years to 1.1/100000 person years(AAPC=0.6;95％CI:0.58 to 0.61).In terms of prevalence and standardized rate of YLD,both women and men showed an upward trend,and the upward trend in women was greater than that in men(AAPC=0.62 vs 0.56).Conclusion The global prevention and control of ROP blindness still faces enormous challenges,and the disease incidence and burden are still on the rise.It is necessary to strengthen screening and improve treatment levels,especially for premature infants under 5-year-old,to reduce the disease burden of ROP related MVI in children and adolescents.
关键词
早产儿视网膜病变/中度视力损伤/疾病负担/儿童青少年
Key words
Retinopathy of premature infants/Moderate vision loss/Disease burden/Children and adolescents
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