辽宁医学杂志2024,Vol.38Issue(5) :24-28.

出血性脑卒中患者血栓弹力图与凝血功能、血小板计数的相关性分析

Correlation analysis of thrombologram with coagulation function and platelet count in patients with hemorrhagic stroke

温羊城 曾洁
辽宁医学杂志2024,Vol.38Issue(5) :24-28.

出血性脑卒中患者血栓弹力图与凝血功能、血小板计数的相关性分析

Correlation analysis of thrombologram with coagulation function and platelet count in patients with hemorrhagic stroke

温羊城 1曾洁1
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作者信息

  • 1. 中山陈星海医院(广东中山 528415)
  • 折叠

摘要

目的 研究出血性脑卒中患者血栓弹力图(TEG)和凝血功能、血小板计数的相关性分析.方法 选择中山陈星海医院2020年6月至2022年10月间收治的80例脑出血患者作为研究对象,将其纳入脑出血组,并根据患者的血肿扩大情况,将其分为血肿扩大组和未扩大组,分别为36例和44例,另选择同时期健康人群30例作为对照组,并对所有研究对象的血栓弹力图、凝血功能等指标进行评估.结果 经过分析后,在凝血功能方面,脑出血组中的D-二聚体(D-D)、纤维蛋白原(FIB)、凝血酶时间(TT)、血小板计数(PLT)均高于对照组,P<0.05,同时活化部分凝血活酶时间(APTT)较之对照组无统计学意义,P>0.05;在血栓弹力图方面,脑出血组的凝血反应时间(R)、血凝块形成时间(K)高于对照组,P<0.05;描记图最大曲线弧度作切线与水平线的夹角(Angel)、描记图最大幅度(MA)低于对照组,P<0.05;在血肿扩大组和未扩大组方面,各个凝血功能指标对比无统计学意义,P>0.05;血栓扩大组的R、K均高于未扩大组,且Angel、MA低于未扩大组.结论 在脑出血患者的凝血功能中,血栓弹力图可起到评估作用,但在凝血药物使用方面的指标作用有限.

Abstract

Objective To study the correlation analysis of thrombologram,coagulation function and platelet count in pa-tients with hemorrhagic stroke.Methods A total of 80 patients with intracerebral hemorrhage admitted to Zhongshan Chenxinghai Hospital from June 2020 to October 2022 were selected as the study objects and included into the intracerebral hemorrhage group.According to the expansion of hematoma of the patients,they were divided into an expanded hematoma group and an unexpanded hematoma group(36 cases and 44 cases,respectively),and 30 healthy people of the same period were selected as the control group.The thromboelasmogram and coagulation function of all subjects were evaluated.Results After analysis,D-dimer(D-D),fibrinogen(FIB),thrombin time(TT)and platelet count(PLT)in the intracerebral hemorrhage group were higher than those in the control group(P;In terms of thromboelastogram,the clotting reaction time(R)and blood clot formation time(K)in the cerebral hemorrhage group were higher than those in the control group(P<0.05);The included angle(Angel)and the maximum amplitude(MA)of the maximum curve radian of the tracing dia-gram between the tangent and the horizontal line were lower than those of the control group(P<0.05);There was no statis-tically significant difference in the coagulation function between the enlarged group and the non-enlarged group(P>0.05);The R and K of the thrombus enlargement group were higher than those of the non-enlargement group,and Angel and MA were lower than those of the non-enlargement group.Conclusion In the patients with cerebral hemorrhage,thrombox-elasmogram can play a role in the evaluation of coagulation function,but it has a limited role in the use of coagulation drugs in cerebral hemorrhage.

关键词

出血性脑卒中/血栓弹力图/凝血功能/血小板计数

Key words

Hemorrhagic stroke/Thromboelastic diagram/Blood coagulation function/Platelet count

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出版年

2024
辽宁医学杂志
辽宁省医学会

辽宁医学杂志

影响因子:0.339
ISSN:1001-1722
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