Objective To investigate the association between serum procalcitonin(PCT),neutrophil/lymphocyte ratio(NLR),serum albumin/globulin ratio(AGR),and forced expiratory volume in the first second in the predicted value(FEV1％pred)and the risk of readmission for acute exacerbation in patients with chronic obstructive pulmonary disease(COPD).Methods A total of 180 patients with COPD admitted to our hospital from March 2020 to March 2022 were se-lected and divided into a stable group(n=77)and an acute exacerbation group(n=103)according to their conditions,and a number of healthy subjects were selected as the control group(n=64).Serum PCT,NLR,AGR and FEV1％pred were compared among the three groups,and the relationship between each index and the risk of readmission for acute exac-erbation was analyzed.Results The PCT,NLR and AGR of acute plus recombinant patients were＞stable group＞control group;The FEV1％pred of acute plus recombinant patients was＜stable group＜control group,the difference among the three groups was statistically significant(P＜0.05),and the pairwise difference among the three groups was statistically significant(P＜0.05).Serum PCT,NLR and AGR were positively correlated with acute exacerbation of COPD(rp=0.608,rn=0.691,rA=0.522,P＜0.001).There was a significant negative correlation between FEV1％pred and COPD exacerbation(rF=-0.726,P＜0.001).The sensitivity of serum PCT,NLR,AGR and FEV1％pred to detect acute exacer-bation of COPD were 62.1％,73.8％,85.4％and 90.3％,respectively.The specificity was 89.6％,88.3％,74.0％,81.8％,respectively.The AUC values were 0.818,0.849,0.795,0.858,respectively.The sensitivity and AUC of FEV1％pred were the highest(P＜0.001),and the specificity of PCT was the highest(P＜0.001).Conclusion PCT,NLR,AGR and FEV1％pred are all independent risk factors of acute exacerbation of COPD.Detection of PCT,NLR,AGR and FEV1％pred can help to diagnose acute exacerbation of COPD.
维普
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