Effect of bladder tumor resection+bladder perfusion and bladder tumor secondary resection+bladder perfusion on recurrence and disease progression in patients with bladder cancer
Effect of bladder tumor resection+bladder perfusion and bladder tumor secondary resection+bladder perfusion on recurrence and disease progression in patients with bladder cancer
Objective To compare the efficacy of bladder tumor resection and secondary resection combined with blad-der perfusion in the treatment of bladder cancer by recurrence rate and disease progression.Methods A total of 99 patients with bladder cancer admitted to our hospital from March 2019 to April 2020 were selected as study subjects.The study sub-jects were divided into a single group(35 cases)and a secondary group(64 cases)according to whether secondary resec-tion was performed.Transurethral resection of bladder tumor(TURBT)combined with bladder perfusion was performed in both groups.Tumor recurrence and disease progression,side effects,postoperative complications,CDH 13 methylation rate and Ki-67 high expression rate before,3 months and 6 months after surgery were compared between the two groups.Results After 2 years of follow-up,the recurrence rate of the single group was 37.14％,which was significantly higher than that of the second group(15.63％);There was no significant difference in the incidence of bladder irritation,gross hematuria,cys-titis and secondary fever between the two groups(P＞0.05).There were no significant differences in the incidence of blad-der irritation,gross hematuria,cystitis and secondary fever between the two groups(P＞0.05).The complication rate of the secondary group was 20.31％higher than that of the single group(2.86％)(P＜0.05).The methylation rate of CDH13 and the high expression rate of Ki-67 in the single group were higher than those in the second group at 3 months and 6 months after surgery(P＜0.05).Conclusion The treatment of bladder cancer patients with secondary electrotomy plus bladder perfusion can reduce the recurrence rate,prolong the survival time,reduce the CDH13 methylation rate and Ki-67 high expression rate,but the risk of postoperative complications is higher.
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