Preparation and Evaluation of Triptolide-Loaded Chitosan Nanoparticles
Objective:To prepare the triptolide-loaded chitosan nanoparticles (TP-CS NPs) and to investigate their physicochemical properties and in vitro release characteristics.Methods:TP-CS NPs were prepared by non-solvent-aided complexation-chemical cross-linking method.Their properties were determined by transmission electron microscopy,particle size analyzer,HPLC and so on.Results:The prepared nanoparticles were spherical with an average size at (151.2 ± 5.4)nm,a Zeta potential at (20.1 ± 1.2) mV,a yield of (78.0 ± 3.3) ％,encapsulation efficiency of (77.0 ± 1.2) ％ and drug loading content of (2.0 ± 0.4) ％.In vitro,the drug release rate was continuously stable in 24 h.Conclusion:TP-CS NPs prepared by non solvent assisted complexation-chemical crosslinking method is convient and reliable,showing a sustained release behavior in vitro.
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