Research Progress of CRISPR-Cas 9 and Its Application in Research of Chinese Medicine
CRISPR/Cas 9 is a genome editing technology invented in recent years.The sgRNA and Cas9 can be used to create a DNA break at a sequence-specific target site,which provides a new platform for human gene editing.CRISPR/Cas 9 originates from the bacterial immune system against the phage and plasmid and it is a simple,efficient,inexpensive genome editing tool.It is called the latest third generation gene editing technology.It was just over three years since it appeared and CRISPR/Cas 9 has been applied to the entire biomedical field.It can be expected that CRISPR-Cas 9 system would also have a huge application prospects in traditional Chinese medicine.It is very important for the traditional Chinese medicine to grasp this opportunity.In this paper,we reviewed the discovery of the CRISPR-Cas system and immune defense mechanism,the invention of the sgRNA-Cas9 gene editing tool as well as the research progress.We also predicted its application in traditional Chinese medicine.
NETL
NSTL
万方数据
维普
