Influence of Dosage on Pharmacokinetics Characteristics of Dahuang in Rats
Objective:To establish an HPLC method of quantitative determination of Dahuang and investigate the influence of dosage on the pharmacokinetics characteristic of Dahuang in rats.Methods:The sample was extracted with Ethyl acetate and was detected by HPLC method.Three doses were adopted to the pharmacokinetics experiment.And pharmacokinetics parameters were calculated by Winnonlin software.Results:Physcion can not be detected in the plasma.No significant difference was found in elimination half-life after intragrastic administration of three doses of Aloe emodin,rhein,emodin and chrysophanol respectively.But Cmax and AUC were increased along with increasing dose.Conclusion:The in vivo process of Aloe emodin,rhein,emodin and chrysophanol was first order linear kinetics.
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万方数据
维普
