Mechanism of Xuefu Zhuyu Capsule(血府逐瘀胶囊)Treating Acute Cerebral Infarction through HIF-1α/NLRP3 Signaling Pathway
Objective To investigate the mechanism of Xuefu Zhuyu Capsule(血府逐瘀胶囊)in the treatment of acute cerebral infarction through hypoxia-inducible factor 1α(HIF-1α)/NOD-like receptor thermal protein domain associated protein 3(NLRP3)signaling pathway,in order to provide a new basis for clinical prevention and treatment of cerebral infarction.Methods A total of 62 patients with acute cerebral infarction admitted to the hospital from December 2022 to December 2023 were analyzed as research objects.They were randomly divided into the study group(Xuefu Zhuyu Capsule)and the control group(talteplase),with 31 cases in each group.The efficacy and adverse reactions of the two groups were analyzed.The TCM syndrome scores,blood flow velocity,the levels of HIF-1α,NLRP3 and caspase-1 and hemorheology indexes were compared before and after treatment.Results The effective rate of the study group and the control group was 96.77％(30/31)and 77.42％(24/31),respectively,and the difference between the two groups was statistically significant(P＜0.05).The scores of hemiplegia,angle skew,dysphagia,speech impairment,dizziness and nausea,dark lips,skin nail disorder and shortness of breath were significantly increased in both groups after treatment(P＜0.05),and the values of peak systolic blood flow velocity(Vs),end diastolic blood flow velocity(Vd)and mean blood flow velocity(Vm)in the study group were significantly higher than those in the control group after treatment(P＜0.05).After treatment,the values of Vs,Vd and Vm in both groups were significantly increased(P＜0.05),and the values of Vs,Vd and Vm in the study group were significantly higher than those in the control group(P＜0.05).The levels of HIF-1α,NLRP3 and caspase-1 in both groups were significantly decreased after treatment(P＜0.05),and the levels of HIF-1α,NLRP3 and caspase-1 in the study group were significantly lower than those in the control group after treatment(P＜0.05).The levels of fibrinogen(FIB),whole blood high shear viscosity(HSV)and plasma viscosity(PSV)in both groups were significantly decreased after treatment(P＜0.05),and the levels of FIB,HSV and PSV in the study group were significantly lower than those in the control group after treatment(P＜0.05).No adverse reactions occurred in both groups during treatment.Conclusion Xuefu Zhuyu Capsule can play a role in treating acute cerebral infarction through HIF-1α/NLRP3 signaling pathway.
万方数据
维普
