Effect of Weishuning(胃舒宁)Combined with Pantoprazole on Clinical Treatment and Serological Indexes of Patients with Duodenal Ulcer
Objective To study the effect of Weishuning(胃舒宁)combined with pantoprazole on clinical treatment and sero-logical indexes of patients with duodenal ulcer.Methods A hundred patients with duodenal ulcer who received treatment in the hospital from January 2019 to January 2023 were selected for this study.According to random number table method,they were di-vided into study group(53 cases)and control group(47 cases).The control group was treated with pantoprazole and the study group was treated with Weishuning combined with pantoprazole.The total effective rates of the two groups,the improvement time of clinical symptoms(acid reflux,low back pain,heartburn)after treatment,the levels of serum indicators[transforming growth factor-α(TGF-α),interleukin-8(IL-8),nitric oxide(NO),nuclear transcription factor kappa B(NF-κB)],gastric mucosa func-tion[gastrin(GAS),pepsinogen-Ⅰ(PG-Ⅰ),pepsinogen-Ⅱ(PG-Ⅱ)]before and after treatment were compared between the two groups.Results After treatment,the total effective rate of the observation group was significantly higher than that of the control group[93.34％(50/53)vs 78.72％(37/47)](P＜0.05).The improvement time for acid reflux,low back pain and heartburn in the study group were significantly shorter than those in the control group[(2.03±0.20)d vs(3.18±0.26)d,(1.67±0.28)d vs(3.29±0.37)d,(2.09±0.31)d vs(3.80±0.42)d](P＜0.05).The levels of TGF-α,IL-8,NO and NF-κB in the observation group were significantly lower than those of the control group[(36.01±3.29)ng/L vs(47.23±3.97)ng/L,(12.29±3.12)ng/L vs(20.86±3.97)ng/L,(12.98±3.06)ng·L-1 vs(27.09+4.21)ng·L-1](P＜0.05).The NO level in the observation group was significantly higher than that of the control group[(86.70±8.92)μmmol/L vs(56.39±7.03)μmmol/L](P＜0.05).The levels of GAS,PG-Ⅰ and PG-Ⅱ in the observation group were significantly lower than those of the control group[(29.61±6.39)mg/mL vs(56.20±7.62)mg/mL,(61.58±15.80)ng/mL vs(83.29±18.62)ng/mL,(23.60±3.85)ng/mL vs(39.67±5.62)ng/mL)(P＜0.05).Conclusion Weishuning combined with pantoprazole can effectively im-prove the clinical symptoms,the function of gastric mucosa and serological indicators of patients with duodenal ulcer,with signifi-cant therapeutic effect.
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