首页|基于数据挖掘的《古今图书集成医部全录》治疗男性不育症用药规律研究

基于数据挖掘的《古今图书集成医部全录》治疗男性不育症用药规律研究

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目的 探讨《古今图书集成医部全录》治疗男性不育症(male infertility,MI)的用药规律,旨在为临床服务.方法 检索《古今图书集成医部全录》治疗MI的方剂,将所得方剂的药物录入中医传承计算平台V3.5软件,运用该系统中的数据分析方法,对药物进行统计分析、关联分析、聚类分析.结果 纳入《古今图书集成医部全录》治疗MI的方剂77首,共使用192味中药.四气分析显示,使用频次最高的是温性药物;五味分析显示,使用频次最高的是甘味药物;归经分析显示,使用频次最高的是归肾经药物;中药分析显示,使用频次排在前10位的中药依次为熟地黄、茯苓、当归、蜂蜜、牛膝、人参、肉苁蓉、枸杞子、菟丝子、杜仲;功效分析显示,使用最多的是补虚类中药,其次是收涩类中药;设置支持度≥20,置信度≥0.7,频次分析显示常用药物组合是"熟地黄-茯苓""熟地黄-当归""熟地黄-蜂蜜""熟地黄-人参";常用用药规则是"巴戟天→肉苁蓉""人参→熟地黄""蜂蜜→熟地黄""肉苁蓉→巴戟天";得到新方3首.结论《古今图书集成医部全录》治疗MI重视补肾填精,滋阴养血,用药纯正平和,温而不燥,固而不涩,补泻兼施,对当代临床治疗MI具有很高的实用价值.
A Study on the Medication Rules for the Treatment of Male Infertility in the Integrated Medical Records of Ancient and Modern Books Based on Data Mining
Objective To explore the medication rules for the treatment of male infertility(MI)in the"Complete Collection of Ancient and Modern Books and Medical Records",and to provide clinical services.Methods Retrieve the prescriptions for trea-ting MI from the Complete Records of the Integrated Medical Department of Ancient and Modern Books,and input the drugs ob-tained into the Traditional Chinese Medicine Inheritance Calculation Platform(V3.5)software.Use the data analysis methods in the system to perform statistical analysis,correlation analysis,and cluster analysis on the drugs.Results77prescriptions for the treatment of MI were included in the Complete Collection of Ancient and Modern Books by the Medical Department,andatotal of 192 traditional Chinese medicines were used.The analysis of the four gases shows that the most frequently used is warm drugs;The analysis of five flavors shows that the most frequently used is the sweet flavored medication;According to the analysis of me-ridians,the most frequently used drugs are those that belong to the kidney meridian;Analysis of traditional Chinese medicine shows that the top10 most frequently used Chinese medicines are Rehmanniaglutinosa,Poriacocos,Angelicasinensis,honey,Achyranthesbidentata,ginseng,Cistanchedeserticola,Gojiberries,Dodderseed,and Eucommiaulmoides;The efficacy analysis shows that the most commonly used Chinese medicine is tonifying deficiency,followed by astringent Chinese medicine;Setasupport score of ≥ 20 and aconfidence level of 0.7.Frequency analysis shows that the commonly used drug combinations are"Rehmannia glutinosa Poria","Rehmannia glutinosa Angelica","Rehmanniaglutinosahoney",and"Rehmannia glutinosa ginseng";The com-monly used medication rules are"Morinda officinalis→Cistanched eserticola","Ginseng→ Rehmanniaglutinosa","Honey→Reh-manniaglutinosa",and"Cistanchedeserticola→Morindaofficinalis";Obtain 3 new songs.Conclusion The"Complete Collection of Ancientand Modern Books from the Medical Department"emphasizes the treatment of MI by nourishing the kidney and essence,nourishingyin and blood,using pure and peaceful medication,warming butnotrestless,fixingbutnot astringent,and combining tonify-ing and purging.It has high practical value for contemporary clinical treatment of MI.

Integrated medical records of ancient and modern booksMalein fertilityData miningMedication patterns

楼立理、田朝晖、张金红、崔应东、李金涛、杨超、宋章兴

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江苏凤凰科学技术出版社,江苏南京 210029

恩施土家族苗族自治州中心医院,湖北恩施 445000

古今图书集成医部全录 男性不育症 数据挖掘 用药规律

2025

辽宁中医杂志
辽宁中医药大学,辽宁省中医药学会

辽宁中医杂志

北大核心
影响因子:0.815
ISSN:1000-1719
年,卷(期):2025.52(1)