首页|观察针刀联合和胃降气汤对难治性胃食管反流病患者疗效的影响

观察针刀联合和胃降气汤对难治性胃食管反流病患者疗效的影响

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目的 探究针刀联合和胃降气汤对难治性胃食管反流病(RGERD)患者疗效的影响和安全性分析.方法 选取2020年1月-2023年1月在医院接受治疗的RGERD患者120例.根据随机数字表将患者分为对照组与研究组,每组各60例.其中对照组患者接受常规治治疗方案.研究组患者在对照组的基础上接受针刀联合和胃降气汤治疗.比较两组的临床效果,统计患者使用治疗前后的反流性疾病问卷(RDQ)评分,中医证候评分,GERD健康相关生活质量评分(GERD-HRQL).统计患者治疗后6个月复发情况,记录患者治疗过程中的不良反应.比较患者治疗前后肿瘤坏死因子(TNF)-α,超敏C反应蛋白(hs-CRP)和白细胞介素(IL)-6,胃泌素(GAS)和胃动素(MOT)水平变化.结果 研究组患者疗效显著高于对照组患者(P=0.045),并且研究组患者临床症状改善率显著高于对照组患者(P=0.003).治疗后研究组患者与对照组患者相比烧心、反酸、反流和胸痛明显降低(P<0.05).治疗后研究组患者与对照组患者相比肝胃郁热、气郁痰阻、胆热犯胃和中虚气逆明显降低,存在差异有统计学意义(P<0.05).治疗后研究组患者与对照组患者相比GERD-HRQL评分明显降低,存在差异有统计学意义(P<0.05).治疗后研究组患者与对照组患者相比TNF-α,hs-CRP和IL-6水平明显降低,研究组患者与对照组患者相比GAS和MOT水平明显升高,存在差异有统计学意义(P<0.05).研究组患者复发率相较对照组明显降低(P=0.030).对照组患者出现不良反应症状的总发生率要显著高于研究组患者(P=0.031).结论 和胃降气汤联合针刀治疗RGERD具有显著效果,两者结合可提高患者疗效,降低患者炎症反应,改善胃动力和生活质量,并具有降低复发率和不良反应的作用.
Influence of Needle Knife and Hewei Jiangqi Decoction(和胃降气汤)on Treatment Efficacy of Patients with Refractory Gastroesophageal Reflux Disease
Objective To explore the effect and safety analysis of needle knife and Hewei Jiangqi Decoction(和胃降气汤)in the treatment of refractory gastroesophageal reflux disease(RGERD)patients.Methods A hundred and twenty RGERD patients in the hospital from January 2020 to January 2023 were equally split into control and research groups.The control group underwent standard treatments,while the research group additionally received needle knife and Hewei Jiangqi Decoction.The clinical outcomes of two groups were compared and the scores of the reflux disease questionnaire(RDQ),traditional Chinese medicine syndrome scores and GERD Health Related Quality of Life Score(GERD-HRQL)were calculated before and after treatment.The recurrence of patients 6 months after treatment and document any adverse reactions were recorded during the treatment process.The changes in tumor necrosis factor(TNF)-α,high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6),gastrin(GAS)and motilin(MOT)were compared before and after treatment.Results The research group showed better therapeutic outcomes(P=0.045)and symptom relief(P=0.003)than the control group.They also displayed fewer traditional symptoms(P<0.05)and improved GERD-HRQL scores(P<0.05).The levels of TNF-α,hs-CRP and IL-6 of the re-search group were significantly lower compared to those of the control group after treatment,and the levels of GAS and MOT of the research group were significantly higher compared to those of the control group,with a statistically significant difference(P<0.05).Their recurrence rate was lower(P=0.030),while the control group experienced more side effects(P=0.031).Conclusion The combination of needle knife and Hewei Jiangqi Decoction and needle knife in the treatment of RGERD has a sig-nificant effect,and can improve the efficacy,reduce the inflammatory response,increase the gastric dynamics and the quality of life.It also has the effect of reducing recurrence rate and the adverse effects.

needle knifeHewei Jiangqi Decoction(和胃降气汤)refractory gastroesophageal reflux diseasetherapeutic effi-cacyrecurrence

刘杨、薛小娜、吕亚楠、国生、刘晓芳、魏培栋

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北京中医药大学东方医院,北京 100078

北京中医药大学东直门医院,北京 100020

针刀 和胃降气汤 难治性胃食管反流病 疗效 复发

2025

辽宁中医杂志
辽宁中医药大学,辽宁省中医药学会

辽宁中医杂志

北大核心
影响因子:0.815
ISSN:1000-1719
年,卷(期):2025.52(1)