Influence of Needle Knife and Hewei Jiangqi Decoction(和胃降气汤)on Treatment Efficacy of Patients with Refractory Gastroesophageal Reflux Disease
Objective To explore the effect and safety analysis of needle knife and Hewei Jiangqi Decoction(和胃降气汤)in the treatment of refractory gastroesophageal reflux disease(RGERD)patients.Methods A hundred and twenty RGERD patients in the hospital from January 2020 to January 2023 were equally split into control and research groups.The control group underwent standard treatments,while the research group additionally received needle knife and Hewei Jiangqi Decoction.The clinical outcomes of two groups were compared and the scores of the reflux disease questionnaire(RDQ),traditional Chinese medicine syndrome scores and GERD Health Related Quality of Life Score(GERD-HRQL)were calculated before and after treatment.The recurrence of patients 6 months after treatment and document any adverse reactions were recorded during the treatment process.The changes in tumor necrosis factor(TNF)-α,high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6),gastrin(GAS)and motilin(MOT)were compared before and after treatment.Results The research group showed better therapeutic outcomes(P=0.045)and symptom relief(P=0.003)than the control group.They also displayed fewer traditional symptoms(P<0.05)and improved GERD-HRQL scores(P<0.05).The levels of TNF-α,hs-CRP and IL-6 of the re-search group were significantly lower compared to those of the control group after treatment,and the levels of GAS and MOT of the research group were significantly higher compared to those of the control group,with a statistically significant difference(P<0.05).Their recurrence rate was lower(P=0.030),while the control group experienced more side effects(P=0.031).Conclusion The combination of needle knife and Hewei Jiangqi Decoction and needle knife in the treatment of RGERD has a sig-nificant effect,and can improve the efficacy,reduce the inflammatory response,increase the gastric dynamics and the quality of life.It also has the effect of reducing recurrence rate and the adverse effects.