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中医药治疗肝硬化腹水的作用机制及临床应用概述

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腹水的产生是肝硬化从代偿期进入失代偿期的标志,是肝硬化失代偿期最主要的并发症之一,其发病机制尚未完全明晰.中医学认为其病病位在肝、脾、肾三脏,基本病机为水停、气结、血瘀相互夹杂致病.近年来,国内学者运用中医药防治肝硬化腹水取得了一定的临床疗效,在缩小腹围、减轻腹胀、增加尿量及改善肝功能等方面展现出独特优势;其作用机制主要集中在降低门静脉高压、利尿、改善炎症介质水平、调节肠道菌群、调控水通道蛋白表达等方面.文章就近年来中医药防治肝硬化腹水相关作用机制及临床应用进行综述,旨在为该病的临床防治提供思路与参考.
Overview of Mechanism and Clinical Application of Traditional Chinese Medicine in Treatment of Cirrhotic Ascites
The development of ascites is a sign that cirrhosis has moved from the compensated to the decompensated phase,and is one of the most significant complications of the decompensated phase of cirrhosis,the pathogenesis of which is not yet fully understood.According to traditional Chinese medicine,the disease is located in liver,spleen and kidney,and the basic pathogene-sis is water retention,Qi stagnation and blood stasis.In recent years,domestic scholars have achieved certain clinical efficacy in the prevention and treatment of ascites in liver cirrhosis,showing unique advantages in reducing abdominal girth,decreasing ab-dominal distension,increasing urine output and improving liver function.Its mechanism of action is mainly focused on reducing portal hypertension,promoting urination,improving the levels of inflammatory mediators,regulating intestinal flora and regulating water channel protein expression.This article reviewed the mechanism of action and clinical application of traditional Chinese medicine in the prevention and treatment of cirrhotic ascites in recent years,with the aim of providing ideas and references for the clinical management of this disease.

cirrhosis ascitestraditional Chinese medicine treatmentmechanism of actioncurrent state of application

梅梦如、李雨、陈炳东、刘美燕、卢昌林、刘志芳、黄小桃、林镛、颜耿杰、龙富立

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广西中医药大学,广西南宁 530200

广西中医药大学第一附属医院,广西南宁 530023

肝硬化腹水 中医药治疗 作用机制 临床应用

2025

辽宁中医杂志
辽宁中医药大学,辽宁省中医药学会

辽宁中医杂志

北大核心
影响因子:0.815
ISSN:1000-1719
年,卷(期):2025.52(1)