Research Progress of Cannabinoid Type Ⅱ Receptor in Femoral Head Necrosis
Cannabinoid type Ⅱ receptor(CB2R)is an important component of the endogenous cannabinoid system,and has been widely used in clinical and research applications because of its analgesic,anti-inflammatory,antiepileptic,anti-fibrotic and bone metabolism modulating effects.In recent years,the use of CB2R for the treatment of a variety of difficult diseases has be-come a research hotspot,especially for the treatment of orthopedic diseases.Currently,there is no definitive method for early to mid-stage femoral head necrosis(ONFH)patients,and because of its anti-inflammatory,pain-relieving,promoting osteogenic differentiation of BMSCs and maintaining bone remodeling homeostasis effects,CB2 has been investigated in the hope that it can become an effective target for the treatment of ONFH.
cannabinoid type Ⅱ receptorosteonecrosis of femoral headinflammatory reactionbone remodelingBMSCs
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