The evaluation of groundwater pollution prevention performance is of great significance for the layout of enterprises in industrial clusters and the protection of shallow groundwater.The strata in the industrial agglom-eration area of Yunyan District are covered karst areas with local karst exposed.The PLEIK model are used to e-valuate the anti-pollution performance of the groundwater in this area.The zoning evaluation map of the anti-pol-lution performance of the groundwater in the study area is obtained through the zoning mapping and superim-posed calculation of the five index systems,and the anti-pollution performance of the industrial agglomeration ar-ea is overall evaluated.The results show that the area with poor anti-pollution performance is mainly Sanma area with strong karst development,which is more affected by human activities and concentrated by industrial enterpri-ses;And the area with good anti-pollution performance is concentrated in the slope area with poor karst develop-ment,which is in the area with thick soil cover and abundant vegetation.The results provide a basis for industrial enterprise layout,land use,enterprise management and follow-up monitoring,and groundwater protection and uti-lization in Yunyan District in the future.