Synthesis and Purity Testing of Hispolon and Piperlonguminine
In this paper,hispolon was obtained by Pabon reaction using acetylacetone and 3,4-dihydroxybenzalde-hyde as raw materials;Piperlonguminine was obtained using Piperine as the raw material.Piperonic acid was got-ten after hydrolysis and acidification.Subsequently,piperonic acid was directly condensed with isobutylamine in the presence of the coupling agent HATU.The total yields for hispolon and piperlonguminine were 70%and 50%respectively.The target molecular structures were characterized by NMR and HR-ESI-MS technique.The purity of hispolon and piperlonguminine exceeded 99%by thin layer chromatography and high-performance liquid chro-matography methods.This synthesis method possess advantages such as easy accessibility of starting materials,mild reaction conditions,straightforward post-processing,and high purity of the products.
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