首页|Engineering the native methylotrophs for the bioconversion of methanol to value-added chemicals:current status and future perspectives
Engineering the native methylotrophs for the bioconversion of methanol to value-added chemicals:current status and future perspectives
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Methanol is becoming an attractive fermentation feedstock for large-scale bioproduction of chemicals,due to its natural abundance and mature production technology.Native methylotrophs,which can utilize methanol as the only source of carbon and energy,are ideal hosts for methanol bioconversion due to their high methanol utili-zation rate and have been extensively employed in the production of value-added chemicals from methanol.Here,we review the natural methanol utilization pathways in native methylotrophs,describing the available synthetic biology tools developed for engineering native methylotrophs,and discuss the strategies for improving their methanol utilization efficiency.Finally,the representative examples of engineering the native methylotrophs to produce value-added products from methanol are summarized.Furthermore,we also discuss the major challenges and possible solutions for the application of native methylotrophs in methanol-based biomanufacturing.
State Key Laboratory of Materials-Oriented Chemical Engineering,College of Biotechnology and Pharmaceutical Engineering,Nanjing Tech University,Nanjing,211816,China
National Key Research and Development Program of ChinaJiangsu Synergetic Innovation Center for Advanced Bio-Manufacture
NETL
NSTL
万方数据
维普
