首页|Type Ⅰ photosensitizer based on AIE chromophore tricyano-methylene-pyridine for photodynamic therapy

Type Ⅰ photosensitizer based on AIE chromophore tricyano-methylene-pyridine for photodynamic therapy

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Image guided photodynamic therapy(PDT)combines fluorescence tracing and phototherapy,which can achieve a more accurate and effective treatment effect.However,traditional photosensitizers are limited by the aggregation-caused fluorescence quenching(ACQ)effect and low reactive oxygen species(ROS)generation in a hypoxic environment,resulting in poor imaging and treatment effect.Herein,we report a tricyano-methylene-pyridine(TCM)-based Type Ⅰ aggregation-induced emission(AIE)photosensitizer(TCM-MBP),the strong elec-tron acceptance(D-A)effect extends the wavelength to near-infrared(NIR)region to reduce the autofluorescence interference,and oxygen atoms provide lone pair electrons to enhance the inter system crossing(ISC)rate,thereby promoting the generation of more triplet states to produce ROS.The AIE photosensitizer TCM-MBP exhibited low oxygen dependence,NIR emission,and higher ROS production compared to commercially avail-able Ce 6 and RB.After encapsulation with DSPE-PEG2000,TCM-MBP nanoparticles(TCM-MBP NPs)could penetrate to visualize cells and efficiently kill cancer cells upon light irradiation.This study provides an oxygen-independent AIE photosensitizer,which has great potential to replace the commercial ACQ photosensitizers.

Aggregation-induced emissionNear-infrared emissionPhotodynamic therapyType ⅠROS

Chao Pan、Weijun Zhao、Xiaolei Zhao、Zhenxing Liu、Xiangyu Li、Yanting Lyu、Xupeng Wu、Zhirong Zhu、Wei-Hong Zhu、Qi Wang

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Shanghai Key Laboratory of Functional Materials Chemistry,Key Laboratory for Advanced Materials and Institute of Fine Chemicals,Joint International Research Laboratory of Precision Chemistry and Molecular Engineering,Feringa Nobel Prize Scientist Joint Research Center,Frontiers Science Center for Materiobiology and Dynamic Chemistry,School of Chemistry and Molecular Engineering,East China University of Science and Technology,Shanghai,200237,China

NSFC Science Center ProgramNSFC/ChinaNSFC/ChinaNSFC/ChinaShanghai Municipal Science and Technology Major Project

217881029195920221974047216226022018SHZDZX03

2023

10.1016/j.gce.2022.07.004

绿色化学工程(英文)
中国科学院过程工程研究所

绿色化学工程(英文)

CSCD
ISSN：
年,卷(期)：2023.4(3)
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