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Fluorescent probes for glucolipid metabolism of bacterial cell wall

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Cell wall is a basic component of bacteria that promotes bacteria to adapt the complicated environment as well as play an essential role in antimicrobial resistance.The structure of bacterial cell wall is remarkably rich,and some complex components,such as peptidoglycan,lipopolysaccharide,and peptidoglycan-arabinogalactan et al.,can only be found in bacteria.Furthermore,the biosynthesis and transfer of these glycolipids are indispensable for bacteria during cell elongation.And the process of biosynthesis and transfer are generally associated with metabolism and sophisticated enzyme mechanisms.However,how the metabolic process takes place,what role enzymes play in this process and how they function have been major concerns for scientists in this field.Numerous significant progresses on fluorescent probes and biological imaging bring opportunity for the studying of metabolism and enzyme mechanisms recently due to its non-invasive and high sensitivity.In this review,we focused on metabolic fluorescent probes for the detection of glycolipids in bacterial cell wall and highlighted the involving mechanisms and biological application.

Fluorescent probesBacteriaCell wallGlucolipid metabolism

Yurou Huang、Xiaoxie Ma、Caimin Gao、Yuan Xie、Mingqiang Qiu、Jun Yin

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Key Laboratory of Pesticide and Chemical Biology,Ministry of Education,Hubei International Scientific and Technological Cooperation Base of Pesticide and Green Synthesis,International Joint Research Center for Intelligent Biosensing Technology and Health,College of Chemistry,Central China Normal University,Wuhan,430079,China

Guangdong Provincial Key Laboratory of Radioactive and Rare Resource Utilization,Shaoguan,512026,China

国家自然科学基金国家自然科学基金高等学校学科创新引智计划(111计划)Scholar Support Program of CCNUExcellent Doctorial Dissertation Cultivation Grant of CCNU from the colleges'basic research and operation of MOEResearch Fund Program of Guangdong Key Laboratory of Radioactive and Rare Resource UtilizationMinistry of Education Key Laboratory for the Synthesis and Application of Organic Functional MoleculesHubei University,Wuhan ,P.R.ChinaOpening fund of Hubei Key Laboratory of Bioinorganic Chemistry &Materia MedicaState Key Laboratory of Chemical Oncogenomics(Shenzhen)

2167611321772054B170190900-311010900022019YBZZ0292018B030322009KLSAOFM2012430062BCMM202101

2023

10.1016/j.gce.2022.08.004

绿色化学工程(英文)
中国科学院过程工程研究所

绿色化学工程(英文)

CSCD
ISSN：
年,卷(期)：2023.4(4)
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