Determination of β—agonist Cimaterol residues in feed by ultra performance liquid chromatography—tandem mass spectrometry
A method for determination of β-agonist Cimaterol residues in feed by ultra per-formance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS)was developed.The samples were extracted with acidified acetonitrile,and purified by QuEChERS method.Ci-materol content was measured by UPLC-MS/MS in the multiple reaction monitoring(MRM)mode by employing the internal standard method.The results indicate that:under the experimen-tal condition,Cimaterol had a good resolution and well linearity(r=0.999 2)in detection ran-ges.The limit of quantification for Cimatrol was 0.5 µg/kg.The average recoveries from spiked blank samples ranged from 88.6％to 102.4％with relative standard deviation(RSD)between 1.9％and 5.1％.With the advantages of convenience,sensitivity,good recoveries and repeat-ability,the method was suitable for the detection of Cimaterol in feed.
feedCimaterolultra performance liquid chromatography-tandem mass spec-trometry(UPLC-MS/MS)determination
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