大变形压痕揭示蛛网膜-软脑膜复合结构对脑组织的力学贡献
Mechanical contribution of the pia-arachnoid complex to brain tissue revealed by large deformation indentation
张弛 1李义强 1赵宏伟1
作者信息
- 1. Key Laboratory of CNC Equipment Reliability,Ministry of Education,Jilin University,Changchun 130025,China;School of Mechanical & Aerospace Engineering,Jilin University,Changchun 130025,China;Institute of Structured and Architected Materials,Liaoning Academy of Materials,Shenyang 110167,China;Chongqing Research Institute of Jilin University,Chongqing 401120,China
- 折叠
摘要
蛛网膜-软脑膜复合结构在维持脑组织生理功能、抵御有害载荷方面发挥至关重要的作用.然而,该结构的力学特性仍不明晰.本研究采用大变形动态压痕技术获取了蛛网膜-软脑膜复合结构的力学响应,通过有限元仿真分析与试验相结合,发现并归纳了该结构在外部载荷作用下的重要的力学特性.研究结果表明,蛛网膜-软脑膜复合结构的存在可以增加大脑皮层的剪切模量和阻尼比,增强脑组织对局部变形的抵抗能力.此外,在遭受大变形时,该结构可以将大脑皮层所承受的最大应力和应变分别降低40％和53％.此外,该结构可以在脑组织松弛时阻止应变向大脑皮层传递.本研究为脑组织有限元模型的完善与蛛网膜-软脑膜复合结构的动态力学特性研究提供了基础数据.
Abstract
The pia-arachnoid complex(PAC)tissue plays a vital role in upholding the physiological functionality of brain tissue and bolstering its capacity to withstand detrimental loads.However,the mechanical attributes of the PAC tissue remain in-adequately comprehended and insufficiently explored.This investigation acquired the indentation response of the PAC tissue through large deformation dynamic indentation.The mechanical significance in the face of external loads of the PAC tissue was elucidated through the combination of finite element simulation and experiment.The findings demonstrated that the PAC tissue can augment the cortex's shear modulus and damping ratio,fortifying the brain tissue's resistance against deformation.Additionally,the outcomes revealed that the PAC tissue can curtail the maximum stress and strain within the brain tissue by 40％and 53％,respectively,when subjected to substantial local deformation.Furthermore,the PAC tissue can impede strain propagation to the cerebral cortex during relaxation.This inquiry furnished a fundamental dataset for char-acterizing the dynamic mechanical properties within finite element simulations and experimental explorations involving brain tissue.
关键词
The pia-arachnoid complex/Large deformation indentation/Finite element simulation/Mechanical property/Brain tissueKey words
The pia-arachnoid complex/Large deformation indentation/Finite element simulation/Mechanical property/Brain tissue引用本文复制引用
基金项目
National Science Fund for Distinguished Young Scholars(51925504)
National Major Scientific Research Instrument Development Project(52227810)
Foundation for Innovative Research Groups of the National Natural Science Foundation of China(52021003)
出版年
2024
NETL
NSTL
万方数据