Comparative assessment of liver tissue:from microstructural and mesoscale vascular architecture to macroscopic mechanics
康巍 1孙开新 1王丽珍 1樊瑜波2
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作者信息
1. Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education,Beijing Advanced Innovation Center for Biomedical Engineering,School of Biological Science and Medical Engineering,Beihang University,Beijing 100083,China
2. Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education,Beijing Advanced Innovation Center for Biomedical Engineering,School of Biological Science and Medical Engineering,Beihang University,Beijing 100083,China;School of Engineering Medicine,Beihang University,Beijing 100083,China
Accurately characterizing the liver's mechanical properties is of paramount importance for disease diagnosis,treatment,surgical prosthetic modeling,and impact injury dummies.However,due to its inherent biological soft tissue nature,the characterization of mechanical behavior varies across testing methods and sample types.In this study,we employed trans-mission electron microscope and Micro CT to observe the morphology of the marginal and center of rat livers and conducted macroscopic mechanical tests to characterize their elasticity and viscoelasticity.The results revealed that the central region displayed higher metabolic levels,elongated mitochondria,and an abundance of rough endoplasmic reticulum at the micro-scale.At the mesoscale,larger diameter portal veins were mainly distributed in the central region,while smaller diameter arteries were predominantly located at the periphery.At the macroscale,under a strain rate of 0.0167 s-1,no significant differences were observed in the elastic properties between the two regions.However,as the strain rate increased up to 0.167 s-1,the central region displayed higher porosity,resulting in reduced liquid loss,increased hardness,and higher viscosity compared to the periphery.Consequently,the liver demonstrated overall heterogeneity,with isotropic models suitable for the peripheral region,while more intricate models may be required to capture the complexity of the central region with its intricate vasculature.
关键词
Liver/Mechanical properties/Micro and macro tests
Key words
Liver/Mechanical properties/Micro and macro tests
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基金项目
National Natural Science Foundation of China(U2241273)
National Natural Science Foundation of China(12172034)
National Natural Science Foundation of China(U20A20390)
National Natural Science Foundation of China(11827803)
Beijing Municipal Natural Science Foundation(7212205)
111 project(B13003)
Fundamental Research Funds for the Central Universities()
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