将短DNA简化成串联的横观各向同性环进行弯曲

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中文摘要：尽管短DNA表现出的高柔性具有重要意义，但对其异常持续长度的机理仍未完全弄清楚。在本研究中，我们建议将短DNA中基因序列的每个基本单元建模为一个横观各向同性环。我们的模型分析成功重演了所观测到的短DNA高柔性，并显示了序列依赖性的影响，与实验结果一致。此外，我们的分析表明，短DNA的弯曲行为可以通过考虑剪切的Timoshenko梁理论进行有效描述。

外文标题：Bending short DNAs as transversely isotropic rings in series

外文摘要：Despite the significance of the high flexibility exhibited by short DNAs,there remains an incomplete understanding of their anomalous persistence length.In this study,we propose to model each basic unit of gene sequences within short DNAs as a transversely isotropic ring.Our comprehensive model analysis successfully replicates the observed high flexibility of short DNAs and also displays the impact of sequence dependence,aligning with experimental findings.Furthermore,our analysis suggests that the bending behavior of short DNAs can be effectively described by the Timoshenko beam theory with the consideration of shear.

外文关键词：

DNAPersistence lengthTimoshenko beam theoryTransversely isotropicBending

作者：

石陈玉、姚美成、陈彬

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作者单位：

Department of Engineering Mechanics,Zhejiang University,Hangzhou 310027,China

Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province,Hangzhou 310027,China

关键词：

DNA Persistence length Timoshenko beam theory Transversely isotropic Bending

基金：

Zhejiang Provincial Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of China

项目编号：

LZ23A0200041237231811872334

出版年：

2024

DOI：

10.1007/s10409-024-24010-x

力学学报(英文版)

CSTPCD

影响因子：0.363

ISSN：0567-7718

年,卷(期)：2024.40(7)