In response to the frequent occurrence of virus diseases and serious harm to the tree and fruit of the Shine Muscat grapevines,different treatments with root fertilizer,root fertilizer+fo-liar spraying were carried out during the leaf-expansion stage,to explore the effects of different fer-tilizer treatments on the improvement of the virus disease and the enhancement of the yield and qual-ity.The results showed that the optimal control effect of the new leaf virus disease was achieved by root application of high nitrogen water-soluble fertilizer 10 kg+humic acid organic water-soluble fertilizer 5 kg per 666.7 m2,and leaf spraying of 5%amino oligosaccharide water 500 times+0.01%28 high brassinolide 1 500 times+seaweed organic water-soluble foliar fertilizer 1 000 times for three times,with an interval of 7 days once.Compared with the control root application of conventional organic water-soluble fertilizer 5 kg+balanced water-soluble fertilizer 5 kg per 666.7 m2,the development of new leaves was always at a lower level,the growth rate of new leaf area was at a higher level,and the quality and yield of grapes were significantly improved.