Comprehensive Research Progress on the Correlation between S-Klotho plus Its Gene and Aging
The Soluble α-Klotho(S-Klotho)protein levels has been identified as a reliable means of assessing the advancement of many age-related ailments,and its decrease is related to pathological alterations of multiple or-gan systems and physiological aging of the body.In recent years,a growing body of research has investigated the correlation between S-Klotho plus its corresponding gene and various age-related ailments.Nevertheless,there is a shortage of evidence about the intervention of disease development by the exogenous administration of S-Klotho.This research provides an overview of the correlation between levels of S-Klotho and the onset and progression of hu-man diseases,the connection between Klotho gene polymorphism and age-related diseases,the association between partial methylation of the Klotho gene promoter and the advancement of age-related diseases,and preclinical inves-tigations on the potential therapeutic effects of exogenous administration of S-Klotho in halting disease progression so as to gain insights into the involvement of this gene in age-related diseases.
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