STUDY ON RESISTANCE OF BHS TO ERYTHROMYCIN AND CLINDAMYCIN AND MECHANISM OF RESISTANCE OT MACROLIDES
Objective To explore the drug resistance and resistance gene carrying status of BHS.Meth-ods The drug sensitivity of BHS to erythromycin and clindamycin was determined by the drug sensitivity disk method,and the resistance genes ermB and mefA to macrolides were detected by PCR.Results The resistance rate of BHS group to erythromycin and clindamycin was high.The positive rate of ermB gene was 84.4%,with GCS and GFS having the highest carrier rate of the gene at 100%.The ermB gene was detected in 7 erythromycin sensitive strains,which did not match the drug resistance phenotype.The posi-tive rate of mefA gene was 3.1%,all of which were detected in erythromycin resistant strains.One strain carries both ermB and mefA genes.Conclusion BHS group has a high resistance rate to macrolides and lin-comamides,and its resistance to erythromycin is mainly related to the methylation of ribosome glycopro-tein.
万方数据
维普
