Objective To explore the treatment and nursing for the patient with unresectable colorectal liver metastases.Methods 60 patients with unresectable l colorectal liver metastases were randomly divided into two groups,with 30 cases in each group.Both groups were treated with CalliSpheres drug-loaded microspheres via transcatheter arterial chemoembolization.The control group received routine nursing,while the observation group received narrative nursing.The effects of tumor control and nursing interven-tion were compared between the two groups.Results The rate of disease control in the observation group was 90%,higher than 66.67%in the control group(χ2=4.81,P=0.028).The improvement degree of SAS,SDS and CD-RISC scores and nursing satisfaction in the observation group were more than those in control group(P<0.05).Conclusion Narrative nursing help to improve the clinical effect of DEB-TACE in treating unresectable colorectal liver metastases and enhance patients'nursing satisfaction.