Objective To explore methods for preventing bone marrow suppression after chemotherapy in malignant tumors.Methods 110 malignant tumor patients who experienced bone marrow suppression after chemotherapy were randomly divided into an observation group(60 cases)and a control group(50 cases).48 hours after the end of this chemotherapy,the observation group received a single subcutaneous injection of PEG-rhG-CSF,while the control group did not receive prophylactic medication.Observe the degree of neutropenia and adverse reactions in two groups.Results The incidence of neutropenia in the ob-servation group was 46.67%,which was higher than 80%in the control group(χ2=12.84,P<0.01);There was no statistically significant difference in the incidence of adverse reactions between the two groups(χ2=0.01,P=0.913).Conclusion The application of PEG-rhG-CSF after chemotherapy in malig-nant tumor patients can alleviate bone marrow suppression and has high safety.
Pegylated recombinant human granulocyte stimulating factorMalignant tumorMyelo-suppressionNeutropenia
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