聚乙二醇化重组人粒细胞刺激因子在预防恶性肿瘤患者化疗后骨髓抑制中的疗效观察
EFFECT OF PEG-rhG-CSF IN PREVENTING BONE MARROW SUPPRESSION AFTER CHEMOTHERAPY IN PATIENTS WITH MALIGNANT TUMORS
乔丽 1张丁方 1李琳琳 1蒋馨莹 1禚永雪 1徐欣 1马德亮 1王友纲1
作者信息
- 1. 临沂市中心医院,山东 沂水 276400
- 折叠
摘要
目的 探讨预防恶性肿瘤化疗后骨髓抑制的方法.方法 将化疗后发生过骨髓抑制的110 例恶性肿瘤患者随机分为观察组(60 例)和对照组(50 例),本次化疗结束 48 h 后,观察组单次皮下注射PEG-rhG-CSF,对照组不预防给药.观察两组中性粒细胞减少程度及不良反应情况.结果 观察组中性粒细胞降低发生率为 46.67%,高于对照组的 80%(χ2=12.84,P<0.01);两组不良反应发生率比较无统计学意义(χ2=0.01,P=0.913).结论 恶性肿瘤患者化疗后应用 PEG-rhG-CSF可减轻骨髓抑制,安全性高.
Abstract
Objective To explore methods for preventing bone marrow suppression after chemotherapy in malignant tumors.Methods 110 malignant tumor patients who experienced bone marrow suppression after chemotherapy were randomly divided into an observation group(60 cases)and a control group(50 cases).48 hours after the end of this chemotherapy,the observation group received a single subcutaneous injection of PEG-rhG-CSF,while the control group did not receive prophylactic medication.Observe the degree of neutropenia and adverse reactions in two groups.Results The incidence of neutropenia in the ob-servation group was 46.67%,which was higher than 80%in the control group(χ2=12.84,P<0.01);There was no statistically significant difference in the incidence of adverse reactions between the two groups(χ2=0.01,P=0.913).Conclusion The application of PEG-rhG-CSF after chemotherapy in malig-nant tumor patients can alleviate bone marrow suppression and has high safety.
关键词
聚乙二醇化重组人粒细胞刺激因子/恶性肿瘤/骨髓抑制/中性粒细胞减少Key words
Pegylated recombinant human granulocyte stimulating factor/Malignant tumor/Myelo-suppression/Neutropenia引用本文复制引用
基金项目
山东省医学会临床科研资金-齐鲁专项(YXH2022ZX02116)
出版年
2024
NETL
NSTL
万方数据