首页|SYNTHESIS AND ANTIPROLIFERATIVE ACTIVITY STUDY OF NOVEL COUMARIN DERIVATIVES

SYNTHESIS AND ANTIPROLIFERATIVE ACTIVITY STUDY OF NOVEL COUMARIN DERIVATIVES

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A series of coumarin derivatives (A01-A13) have been designed and synthesized,and their biological activities were evaluated in vitro in 5 different cell lines:Liver hepatocellular cells (HepG2),breast cancer cells (MCF-7),human malignant melanoma cells (A375),human colonic carcinoma (HT-29) and non-small cell lung cancer cells (A549).Furthermore,A05 was screened in kinase sets and the results showed that the possible targets of it were MST3/STK24 and TNIK.Compounds A01 and A05 displayed the most potent antiproliferative activities in vitro,which suggested that the picolinamide moiety was important for antiproliferative activities.Compound A05 was screened against a set of kinases and the results indicated the kinases MST3/STK24 and TNIK as possible targets.

SynthesisCoumarinAntiproliferative activityTargetin vitro

ZHANG Keping、WEN Kai、LIU Zunfeng、ZHOU Xiang

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Changzhou Health Vocational and Technical School, Changzhou 213002, China

China Pharmaceutical University, Nanjing 210000, China

Key Laboratory of Functional Polymer Material, Ministry of Education, College of Pharmacy Nankai University, Tianjin 300071, China

Youth project of National Natural Science Foundation of ChinaFundamental research funds for the Central Universities江苏高校“青蓝工程”基金常州卫生高职校课题

81102318/H3001JKQ2009013苏教师[2014]23号CW201610

2018

离子交换与吸附
南开大学

离子交换与吸附

CSTPCD北大核心
影响因子：0.515
ISSN：1001-5493
年,卷(期)：2018.34(5)
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