Preparation and Biomedical Applications of Zwitterionic Hydrogels
Zwitterionic hydrogels are a kind of gels formed by zwitterionic polymers.The anionic and cationic groups in their molecular structures can form a dense hydration layer by tightly binding with water.This electrostatic interaction-induced hydration endows zwitterionic hydrogels with extremely low bioadhesion and enables them to effectively resist adhering non-specific proteins,cells,bacteria,etc.,thus leading to their pretty low immunogenicity.These properties render zwitterionic hydrogels promising for biomedical applications.This review first introduces the structure and properties of zwitterionic hydrogels,then summarizes their classification and preparation methods,and further highlights their applications in biomedical fields such as tissue engineering,drug delivery,wound dressings,biosensors,and hydrogel coatings for medical devices.Finally,the future development direction of zwitterionic hydrogels are discussed.
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