Study on the Relationship between Ki67,HER-2,SATB2 and Clinical Pathological Characteristics of Color-ectal Cancer Patients
Objective To analyze the relationship between nuclear associated antigen(Ki67),human epidermal growth factor receptor-2(HER-2),special AT-rich sequence-binding protein 2(SATB2),and clinical pathological characteristics of colorectal cancer(CRC)patients.Methods 91 CRC patients who underwent surgical resection in the hospital from January 2020 to March 2024 were included in this study.Cancerous and adjacent tissues were collected,and the positive expression of Ki67,HER-2,and SATB2 was recorded using immunohistochemistry.Clinical and pathological characteristics of the patients were documented to analyze the correlation between Ki67,HER-2,SATB2,and patient characteristics.Results The positive expression rates of Ki67 and HER-2 in CRC tissues were higher than those in adjacent tissues,while the positive expression rate of SATB2 was lower than that in adjacent tissues(P<0.05).There was a statistically significant difference(P<0.05)in the positive expression rates of Ki67,HER-2,and SATB2 among pa-tients with different clinical stages and lymph node metastasis status.Logistic regression analysis showed that the positive expression of Ki67,HER-2,and SATB2 was found to be associated with clinical staging and lymph node metastasis in CRC patients(P<0.05).Con-clusion The positive expression of Ki67,HER-2,and SATB2 is associated with clinical stage and lymph node metastasis in CRC pa-tients.
Colorectal cancerNuclear proliferation antigenRich in AT sequence binding protein 2Clinical pathological signsrelevance
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