A study on the correlation between SII and delayed cerebral ischemic events in patients with aneurysmal subarachnoid hemorrhage
Objective To investigate the relationship between systemic immune-inflammation index(SII)after the onset of an-eurysmal subarachnoid hemorrhage(aSAH)and delayed cerebral ischemia(DCI).Methods A retrospective analysis was conducted on the clinical data of 223 aSAH patients treated at the Department of Neurosurgery,Affiliated Hospital of Changzhi Medical College,from January 2016 to January 2023.Patients were divided into two groups according to the occurrence of DCI after aSAH:71 in the DCI group and 152 in the non-DCI group.Univariate analysis and multivariate logistic regression analyses were utilized to compare SII levels between the groups,and the predictive value of SII was analyzed by constructing a receiver operating characteristic(ROC)curve.Re-sults Significant differences were observed between the DCI and non-DCI groups in terms of the modified Fisher grade,Hunt-Hess grade,hemoglobin(HGB),white blood cells count,absolute neutrophil count(ANC),absolute lymphocyte count(ALC),platelet count(PLT),neutrophil-lymphocyte ratio(NLR)and SII(P<0.05).Multivariate logistic regression analysis showed that a higher modified Fisher grade(III-IV)(P<0.05),increased ANC(P<0.05)and elevated SII(P<0.05)were independent risk factors for the occur-rence of DCI.The ROC curve showed that the area under the curve(AUC)for SII predicting DCI after aSAH was 0.764[95%CI(0.693-0.835),P<0.05].Patients with a higher SII at admission had higher rates of acute hydrocephalus and DCI,higher modified Fisher and Hunt-Hess grades and worse prognosis.Conclusion Early elevation of SII can independently predict the occurrence of DCI in patients with aSAH.
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