首页|脾氨肽口服冻干粉联合抗生素治疗老年2型糖尿病合并急性肾盂肾炎

脾氨肽口服冻干粉联合抗生素治疗老年2型糖尿病合并急性肾盂肾炎

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目的 探讨脾氨肽口服冻干粉(Spleen Aminopeptide Oral Lyophilized Powder,SAOLP)联合抗生素治疗 2 型糖尿病(Type 2 Diabetes Mellitus,T2DM)合并急性肾盂肾炎(Acute Pyelonephritis,APN)的疗效.方法 收集 2022 年 6 月至 2023 年 6月在牡丹江医科大学附属红旗医院内分泌科住院的 80 例T2DM合并APN老年患者,采用随机数字表法将患者随机分为两组:联合治疗组 40 例,接受SAOLP联合抗生素治疗;单独治疗组 40 例,仅使用抗生素治疗.结果 联合治疗组的白细胞计数(White Blood Cell,WBC)、中性粒细胞百分比(Neutrophil Percentage,NEU%)、降钙素原(Procalcitonin,PCT)、C反应蛋白(C-Reactive Protein,CRP)、白介素-6(Interleukin-6,IL-6)、肝素结合蛋白(Heparin-Binding Protein,HBP)水平均低于单独治疗组(P<0.05);CD4+细胞百分比(Percentage of CD4+Cells,CD4+%)、CD4+/CD8+比率、免疫球蛋白G(Immunoglobulin G,IgG)水平高于单独治疗组(P<0.05).此外,联合治疗组在空腹血糖(Fasting Blood Glucose,FBG)达标时间、体温恢复时间、厌食缓解时间、排尿不适缓解时间、肾区叩击痛缓解时间以及住院日数方面均少于单独治疗组(P<0.05).随访 1 年后,联合治疗组的APN复发率低于单独治疗组(P<0.05);CD4+%、CD4+/CD8+比率及IgG水平高于单独治疗组(P<0.05).结论 SAOLP 可改善T2DM老年患者的免疫功能,与抗生素联合应用可增强抗生素治疗APN的效果.
Spleen Aminopeptide Oral Lyophilized Powder Combined With Antibiotics for the Treatment of Elderly Patients With Type 2 Diabetes Mellitus and Acute Pyelonephritis
Objective To explore the efficacy of spleen aminopeptide oral lyophilized powder(SAOLP)combined with antibiot-ics in treating type 2 diabetes mellitus(T2DM)complicated by acute pyelonephritis(APN).Methods A total of 80 elderly inpatients with T2DM and APN admitted to the Endocrinology Department of Hongqi Hospital affiliated with Mudanjiang Medical University from June 2022 to June 2023 were randomly divided into two groups using a random number table method:a single treatment group(40 ca-ses),receiving antibiotics only and a combined treatment group(40 cases),receiving SAOLP combined with antibiotics.Results The combined treatment group showed lower levels of white blood cell(WBC)count,neutrophil percentage(NEU%),procalcitonin(PCT),C-reactive protein(CRP),interleukin-6(IL-6)and heparin-binding protein(HBP)compared to the single treatment group(P<0.05).Additionally,the combined treatment group had a higher percentage of CD4+cells(CD4+%),CD4+/CD8+ratio and immu-noglobulin G(IgG)levels(P<0.05).Furthermore,the combined treatment group achieved faster recovery in terms of fasting blood glu-cose(FBG)target time,body temperature recovery,alleviation of anorexia,urinary discomfort,renal area tenderness and shorter hospital stays compared to the single treatment group(P<0.05).After a 1-year follow-up,the recurrence rate of APN was lower in the com-bined treatment group,with higher levels of CD4+%,CD4+/CD8+ratio and IgG compared to the single treatment group(P<0.05).Con-clusion SAOLP can improve immune function in elderly patients with T2DM and its combination with antibiotics significantly en-hances the therapeutic efficacy of antibiotics in treating APN.

Type 2 diabetes mellitusacute pyelonephritiselderly patientsspleen aminopeptide oral lyophilized powderantibi-otics

王德平、郭长秀、庄天微、孙毓晗

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牡丹江医科大学附属红旗医院内分泌代谢科,黑龙江 牡丹江 157011

牡丹江医科大学附属红旗医院营养科,黑龙江 牡丹江 157011

2型糖尿病 急性肾盂肾炎 老年病人 脾氨肽口服冻干粉 抗生素

2025

牡丹江医学院学报
牡丹江医学院

牡丹江医学院学报

影响因子:0.615
ISSN:1001-7550
年,卷(期):2025.46(1)