Impact of Ginkgolide on Postoperative Neuroinflammation,Event-Related Potential P300 and Cognitive Function in Elderly Patients Undergoing Noncardiac Surgery Under General Anesthesia
Objective To explore the inhibitory effect of ginkgolide pretreatment on postoperative neuroinflammation in elderly patients undergoing non-cardiac surgery with general anesthesia,as well as its impact on event-related potential P300 and postoperative cognitive function.Methods Eighty elderly patients scheduled for elective non-cardiac surgery under general anesthesia were randomly selected and assigned to the control group or the ginkgolide pretreatment group using a random number table.The ginkgolide pretreat-ment group was further divided into low-dose(4 mg per administration),medium-dose(6 mg per administration)and high-dose sub-groups(10 mg per administration),with 20 cases in each subgroup.On the day before surgery and at one and seven days postoperative-ly,the levels of Matrix Metalloproteinases 9(MMP-9),Phospholipase A2(Lp-PLA2),interleukin-6(IL-6),and tumor necrosis factor α(TNF-α)were measured for all patients and changes in event-related potential P300 were recorded.Concurrently,cognitive function was assessed using the MMSE scale.Results There were no significant differences between the control group and the ginkgol-ide pretreatment group in terms of gender,age,body mass index and operation time.Compared with preoperative levels,the plasma con-centrations of MMP-9,Lp-PLA2,IL-6 and TNF-α significantly increased postoperatively in all groups.However,compared with the control group,patients in the ginkgolide pretreatment group exhibited significantly reduced plasma concentrations of these inflammatory markers postoperatively,shortened P300 latency,enhanced amplitude and improved MMSE scores(P<0.05).Conclusion Ginkgolide pretreatment significantly suppressed neuroinflammation in elderly patients undergoing non-cardiac surgery with general anesthesia,re-duced P300 latency,enhanced amplitude and improved MMSE scores,providing protection for cognitive function.
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