Incidence and influencing factors of exposure keratitis in ICU patients:A Meta-analysis
Objective To investigate the incidence and influencing factors of exposure keratitis in ICU patients,providing evi-dence-based reference for the prevention of exposure keratitis.Methods A computer-assisted search was conducted in databases in-cluding CNKI,Wanfang Data Knowledge Service Platform,VIP,CBM,PubMed,Embase,Cochrane Library,Web of Science,and CI-NAHL for studies on the incidence and influencing factors of ICU exposure keratitis published up to June 2024.Meta-analysis was per-formed using Stata18.0.Results A total of 14 articles involving 2 938 patients and 28 influencing factors were included.The incidence of ICU exposure keratitis was 30.1%(95%CI=20.9%～40.2%).Time of hospitalization≥5 days(OR=6.27,95%CI=0.97～40.58),treated with mechanical ventilation/tracheotomy intubation(OR=7.11,95%CI=3.20～15.8),Mechanical ventilation time≥7 days(OR=7.11,95%CI=3.20～15.8),time of mechanical ventilation(OR=1.13,95%CI=1.05～1.22),use of sedative(OR=2.74,95%CI=1.58～4.75),use of neuromuscular blockers(OR=0.41,95%CI=0.02～9.43),incomplete eye fissure closure(OR=10.89,95%CI=5.61～21.13),eyeball exposure(OR=5.73,95%CI=0.41～81.03),conjunctival oedema(OR=4.67,95%CI=2.20～9.91),perior-bital oedema(OR=5.73,95%CI=0.41～81.03),eyeblink reflex:5 times/min(OR=0.99,95%CI=0.01～82.13),other ocular symp-toms:ocular surface secretion(OR=11.04,95%CI=2.13～57.30)(P<0.05)were identified as influencing factors for exposure keratitis in the ICU.Conclusion The incidence of ICU exposure keratitis remains at a high level and ocular examinations on ICU day 5 and me-chanical ventilation day 7 can prevent the occurrence of ICU exposure keratitis.
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