Objective To systematically evaluate the association between the rs1801282/rs3856806 polymor-phisms of the peroxisome proliferator-activated receptor(PPAR)-γ gene and atherosclerotic disease.Methods The China National Knowledge Network,Wanfang Journal Database,PubMed,Web of Science,and China Biomedical Literature Database were searched by computer,and the retrieval time was from database estab-lishment to 9 December 2021.According to the inclusion and exclusion criteria,all case-control studies that were in line with the rs1801282/rs3856806 polymorphisms of the PPAR-γ gene and associated with athero-sclerotic disease were screened and included.R software was used to perform a meta-analysis of the includ-ed literature.Correlations were assessed based on theORvalue and 95% CI.The Begg's test and a funnel plot were used to identify publication bias.Results A total of 36 studies were included involving 23,395 subjects.The meta-analysis showed that PA and AA gene carriers at rs1801282 were 1.30-fold more likely to develop atherosclerotic disease than PP gene carriers(OR=1.30,95% CI1.05-1.60,P<0.05),carrying the A allele had a 1.24-fold increased risk of carrying the P gene(OR=1.24,95% CI1.04-1.48,P<0.05),and CT and TT gene carriers at rs3856806 were 0.78-fold more likely to be CC gene carriers(OR=0.78,95% CI0.63-0.96,P<0.05).Subgroup analysis showed that the rs1801282 polymorphism was significantly associated with other subgroups and coronary heart disease subgroups,while the rs3856806 poly-morphism was significantly associated with Chinese ethnicity,coronary heart disease,and myocardial infarc-tion subgroups.There was no significant publication bias in the included literature.Conclusions The rs1801282 and rs3856806 polymorphisms of the PPAR-γ gene are shown to be significantly correlated with the incidence of atherosclerotic disease.The PA and AA genotypes and allele A of the rs1801282 polymor-phism may be risk factors for the incidence of atherosclerotic disease.The CT and TT genotypes at rs3856806 may be protective from atherosclerotic disease.
维普
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