Objective To compare the survival rates of hepatic arterial perfusion chemotherapy(HAIC)and systemic chemotherapy in the treatment of secondary malignant tumors of the liver(LSM).Methods Forty-nine patients with LSM who were admitted to the Sinopharm Dongfeng General Hospital from January 2021 to September 2022 were selected and divided into HAIC(n=25)and systemic chemotherapy groups(n=24).The first HAIC or systemic chemotherapy administration was designated as the starting point and patient death or the last follow-up evaluation was designated as the endpoint.The follow-up deadline was 14 No-vember 2022.The Kaplan-Meier method and log-rank test results were used to compare differences between the groups.Multivariate analysis was performed using a Cox regression model.Results Objective response rate(ORR)and tumor control rate(TCR)of HAIC group were 28.00％and 84.00％,respectively,those of systemic chemotherapy group were 16.67％and 50.00％,respectively,the ORR between the two groups was no significantly different(P>0.05),the TCR between the two groups was significantly different(P<0.05).The HAIC and systemic chemotherapy group overall survival(OS)rates in 3 months,6 months,and after 1 year were 100.00％,68.00％,32.00％,and 66.67％,33.33％,4.17％,respectively.The OS rates be-tween the two groups were significantly different(P<0.05).The HAIC and systemic chemotherapy group progression-free survival(PFS)rates at 3 months,6 months,and after 1 year were 96.00％,68.00％,32.00％,and 45.83％,29.17％,and 4.17％,respectively.The PFS rates between the two groups were significantly dif-ferent(P<0.05).Cox regression model showed therapeutic method was independent prognosis factor for OS and PFS.Conclusions HAIC can significantly prolong the survival time of patients with LSMs com-pared to systemic chemotherapy.
关键词
经导管肝动脉灌注化疗/肝继发性恶性肿瘤/生存分析
Key words
Hepatic arterial perfusion chemotherapy/Secondary malignancies of the liver/Survival analysis
维普
万方数据