摘要
目的 探讨福建省年轻结直肠癌患者发病的危险因素.方法 选取2015-2022年福州市晋安区医院106例病理诊断为结直肠癌患者为观察组,选择同期福州市晋安区医院106名健康体检者为对照组,收集并分析两组身高、体质量、人口学信息、个人史、家族史和饮食生活方式等资料.直肠癌发病影响因素采用多因素logistic回归分析.结果两组平均年龄、性别、长期居住地和教育程度比较差异无统计学意义(P>0.05).观察组体质量指数(body mass index,BMI)水平和炎症性肠病史、结直肠癌家族史比例显著高于对照组,每日食用新鲜蔬菜、新鲜水果和饮用乳制品比例显著低于对照组,差异均有统计学意义(P<0.05).高血压病、糖尿病、饮酒、吸烟、体育锻炼、久坐≥4 h/d及每日食用红肉或加工肉类方面,两组比较差异无统计学意义(P>0.05).多因素分析显示,BMI和结直肠癌家族史与结直肠癌的发生呈正相关,OR值分别为1.351和1.996;每日食用新鲜蔬菜和新鲜水果与结直肠癌的发生呈负相关,OR值分别为0.518和0.469.结论 超重或肥胖和结直肠癌家族史是年轻结直肠癌患者发病的独立危险因素,每日食用新鲜蔬菜和新鲜水果是其保护因素.
Abstract
Objective To evaluate the risk factors of young patients with colorectal cancer in Fujian Prov-ince.Methods Case-control study was used to collect the information from patients who were first patho-logically diagnosed with colorectal cancer and healthy controls.All cases were less than 50 years old.The information include height,weight,demographic characteristics,disease history,family history of diseases,diet and lifestyles.Results A total of 106 patients with colorectal cancer were included as case group and 106 healthy subjects as control group.There were not significant differences on age,sex,long-term resi-dence and education between the two groups.The body mass idex(BMI)level,rateof history of inflamma-tory bowel disease and rateof family history of colorectal cancer in case group were significantly higher than that in control group.However,the proportion of daily eating fresh vegetables and fruits and drinking dairy products were significantly lower than that in control group(P<0.05).There were not significantly statisti-cal differences between the two groups in hypertension,diabetes,alcohol consumption,smoking,physical ac-tivity,average daily sedentary time≥4 hours,and daily consumption of red meat or processed meat.Multi-variate analysis showed that BMI level(OR=1.351)and family history of colorectal cancer(OR=1.996)were positively correlated with the incidence of colorectal cancer.However,daily consumption of fresh vege-tables(OR=0.518)and fresh fruits(OR=0.469)were negatively correlated.Conclusions Overweight or obesity and family history of colorectal cancer were independent risk factors for young patients with colorectal cancer in Fujian Province.And daily consumption of fresh vegetables and fresh fruits were protective factors.
维普
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