摘要
目的 分析糖尿病患者超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)、白细胞介素-2(interleu-kin-2,IL-2)、肿瘤坏死因子α(tumor necrosis factor α,TNF-α)、胰岛素抵抗指数(insulin resistance index,HOMA-IR)与抑郁的相关性.方法 从2020年2月至2023年2月萧县城东医院收治的糖尿病患者中选择研究对象,其中合并抑郁患者(抑郁组)与非合并抑郁患者(非抑郁组)各62例,比较两组一般资料及空腹血糖(fasting plasma glucose,FPG)、餐后2 h血糖(2 hours postprandial glucose,2 h PBG)、糖化血红蛋白(glycosylated he-moglobin,HbAlc)、hs-CRP、IL-2、TNF-α、HOMA-IR、Zung抑郁自评量表(self-rating depression scale,SDS)评分指标;采用Pearson相关分析抑郁组各变量的相关性,采用ROC分析各变量预测糖尿病合并抑郁的效能;采用logistic回归分析糖尿病合并抑郁的危险因素.结果 抑郁组病程[(15.82±1.93)年],长于非抑郁组[(12.58±1.38)年],抑郁组FPG[(10.37±1.95)mmol/L]、2 h PBG[(14.25±2.12)mmol/L]、HbAlc[(8.87±0.84)%]、hs-CRP[(6.32±2.58)mg/L]、IL-2[(189.85±24.78)pg/mL]、INF-α[(11.83±2.44)ng/L]、HOMA-IR(4.85±1.84)、SDS评分[(59.27±8.14)分]高于非抑郁组[(9.14±1.58)mmol/L、(13.09±1.84)mmol/L、(7.84±0.79)%、(3.13±1.06)mg/L、(3.53±1.59)pg/mL、(114.43±13.48)ng/L、(7.74±2.13)、(41.27±7.21)分],P<0.05;Pearson相关分析显示,抑郁组hs-CRP、IL-2、INF-α、HOMA-IR与SDS评分呈正相关(r=0.35,P<0.01;r=0.42,P<0.01;r=0.32,P<0.05;r=0.36,P<0.01);ROC分析显示,hs-CRP、IL-2、INF-α、HOMA-IR评估糖尿病合并抑郁的AUC值为 0.78、0.76、0.69、0.81(P<0.05);logistic回归显示,病程(OR=2.28)、INF-α(OR=3.33)、HOMA-IR(OR=3.25)是糖尿病合并抑郁的独立危险因素(P<0.05).结论 糖尿病患者炎症因子及HOMA-IR水平与其抑郁情绪存在相关性,可作为预测糖尿病合并抑郁的参考指标.
Abstract
Objective To analyze the correlation between hypersensitive C-reactive protein(hs-CRP),interleukin-2(IL-2),tumor necrosis factor α(TNF-α),insulin resistance index(HOMA-IR)and depression in diabetic patients.Methods Patients with diabetes admitted by Xiaoxian Chengdong hospital from February 2020 to February 2023 were selected as subjects,including 62 patients with depression(de-pression group)and 62 patients without depression(non-depression group).General data,blood glucose,hs-CRP,IL-2,TNF-α,HOMA-IR and Zung self-rating depression scale(SDS)were compared be-tween the two groups.Pearson correlation was used to analyze the correlation of variables in depression group,and ROC was used to analyze the predictive efficacy of variables in diabetes mellitus combined with depression.Results The duration of depression group(15.82±1.93)years was longer than(12.58±1.38)years of non-depression group.The FPG(10.37±1.95)mmol/L,2hPBG(14.25±2.12)mmol/L,HbAlc(8.87±0.84)%,hs-CRP(6.32±2.58)mg/L,IL-2(189.85±24.78)pg/mL,TNF-α(11.83±2.44)ng/L,HOMA-IR(4.85±1.84)and SDS(59.27±8.14)scores of the depressive group were higher than those of the non-depressive group(9.14±1.58)mmol/L,(13.09±1.84)mmol/L,(7.84±0.79)%,(3.13±1.06)mg/L,(3.53±1.59)pg/mL,(114.43±13.48)ng/L,(7.74±2.13),(41.27±7.21)points(P<0.05).Pearson corre-lation analysis showed that hs-CRP,IL-2,TNF-α and HOMA-IR in the depression group were positive-ly correlated with SDS score(r=0.35,P<0.01;r=0.42,P<0.01;r=0.32,P<0.05;r=0.36,P<0.01).ROC analysis showed that the AUC values of hs-CRP,IL-2,TNF-α and HOMA-IR in the evaluation of dia-betes mellitus with depression were 0.78,0.76,0.69 and 0.81(P<0.05).Logistic regression showed that disease duration(OR=2.28),TNF-α(OR=3.33)and HOMA-IR(OR=3.25)were independent risk fac-tors for diabetes mellitus with depression(P<0.05).Conclusion The levels of inflammatory factors and HOMA-IR in diabetic patients are correlated with depressive mood,which can be used as a reference index to predict diabetes complicated with depression.
维普
万方数据