Objective To investigate the relationship between serum uric acid(UA),C-reactive protein(CRP),lactate dehydrogenase(LDH)and the severity of acute heart failure and their predictive value for survival,so as to provide reference for clinical intervention.Methods A total of 100 patients with acute heart failure admitted to our hospital from February 2020 to February 2023 were prospectively selected as research objects.Serum UA,CRP and LDH levels of patients with different disease degrees and cardiac function grades were compared at admission.The correlation between serum UA,CRP and LDH levels and the severity and cardiac function grade of patients with acute heart failure was analyzed.After 6 months of follow-up,the prognosis was evaluated according to the survival status of patients.The serum UA,CRP and LDH levels of patients with different prognosis were compared at admission and 1 month after admission.The predictive value of serum UA,CRP and LDH levels on survival of patients was analyzed.Results The levels of serum UA,CRP and LDH in patients with different disease degrees were compared:severe>moderate>mild(P<0.05).The levels of serum UA,CRP and LDH in patients with different cardiac function grades were compared:severe>moderate>mild(P<0.05).The results of correlation analysis showed that serum UA,CRP and LDH levels were positively correlated with the severity of acute heart failure and cardiac function grade(P<0.05).Compared with the survival group,the serum UA,CRP and LDH levels in the death group were higher at admission and 1 month after admission,and the differences were more significant after 1 month admission(P<0.05).The AUC of serum UA,CRP and LDH levels for death of patients with acute heart failure 1 month after admission was 0.795,0.832 and 0.856,respec-tively,and the AUC of combined prediction of all indexes was 0.927,which was greater than that of sin-gle index.Conclusion Serum UA,CRP and LDH are significantly correlated with the severity of acute heart failure and cardiac function,which provides a reference for clinical evaluation of patients'survival sta-tus,so as to formulate corresponding intervention programs and improve prognosis.
维普
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