Study on serum 25-(OH)-D level and NAFLD in physical examination population in Jinzhou
Objective To analyze the correlation between 25-hydroxyvitamin D level and nonalcohol fatty liv-er disease(NAFLD)in population in Jinzhou.Methods A total of 1,975 healthy subjects were recruited from the Physical Research Center of the First Affiliated Hospital of Jinzhou Medical University,subject data was collected and sorted for a cross-sectional study.Based on the ultrasound results,participants were divid-ed into a non-alcoholic fatty liver group(NAFLD)and a control group.Differences in vitamin D levels and clinical metabolic indices were compared between two groups.Spearman correlation was used to analyze the 25-(OH)-D correlation with NAFLD.According to the vitamin D deficiency criteria,it was divided into defi-ciency group(<20 ng/mL),insufficient group(20-30 ng/mL)and appropriate group(≥30 ng/mL).The risk of inter-group NAFLD was evaluated by binary logistic regression analysis.Results Except for the two in-dices 25-(OH)-D and HDL-C,the other indices in the NAFLD group were higher and the difference was statistically significant compared to the control group(P<0.05).The 25-(OH)-D deficiency rate in NAFLD group was significantly higher than that in control group(P<0.05).Serum 25-(OH)-D was negatively corre-lated with NAFLD(r=-0.148,P<0.001).Taking the deficiency group as reference,before adjusting for con-founding factors,the insufficient group was not associated with the the deficient group,the normal level group was negatively correlated with the defective group(P<0.05).After adjusting for many confounding fac-tors,the risk in insufficient group and optimal level group was 0.595 times and 0.580 times higher,com-pared with deficiency group,which showed a distinct negative correlation.Conclusions Due to the high incidence of vitamin D deficiency and NAFLD in Jinzhou area,it should be paid attention to.Diet and life-style should be adjusted and optimized reasonably.25-(OH)-D deficiency may increase the risk of NAFLD.
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