首页|18例含多柔比星脂质体的R-miniCHOP方案联合来那度胺治疗老年初治弥漫大B细胞淋巴瘤的效果

18例含多柔比星脂质体的R-miniCHOP方案联合来那度胺治疗老年初治弥漫大B细胞淋巴瘤的效果

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目的 观察含多柔比星脂质体的R-miniCHOP方案联合来那度胺治疗老年初治弥漫大细胞淋巴瘤(diffuse large B-cell lymphoma，DLBCL)的效果及安全性。方法 回顾性分析2019年1月至2021年1月内蒙古自治区人民医院收治的初发18例老年(≥70岁)初治DLBCL患者，均以含多柔比星脂质体的R-miniCHOP方案联合来那度胺口服治疗。随访患者恢复情况。结果 18例患者治疗完全缓解(complete response，CR)38。89%、部分缓解(partial response，PR)33。33%、疾病进展(progressive disease，PD)11。11%，总有效72。22%。不良反应主要有肝损害、血液学毒性等，经对症治疗缓解。结论 含多柔比星脂质体的R-miniCHOP方案联合来那度胺对于治疗老年弥漫大B细胞淋巴瘤，患者多可耐受、疾病稳定性好、生活质量高。
The effect of R-minichop combined with pegylated liposomal doxorubicin and lenalidomide in the treatment of 18 cases diffuse large B-cell lymphoma in the elderly
Objective To observe the efficacy and safety of R-minichop combined with pegylated liposomal doxorubicin and lenalidomide in the treatment of diffuse large B-cell lymphoma in the elderly patients.Methods From January 2019 to January 2021,18 patients with diffuse large B-cell lymphoma aged over 70 years were treated with R-minichop combined with pegylated liposomal doxorubicin and lenalidomide Pa-tients are followed up on their recovery.Results In 18 patients,38.89% of the patients had complete re-mission,33.33% had partial remission and 11.11% had disease progression,the total effective rate was 72.22%.The adverse reactions mainly include liver damage,hematological toxicity,etc.most of them can be relieved by symptomatic treatment.Conclusion R-minichop combined with pegylated liposomal doxoru-bicin and lenalidomide is a good treatment for elderly patients with diffuse large B-cell lymphoma,which is more tolerable and has a stable quality of life.

Diffuse large B-cell lymphomaElderlyCombination medicationsAdverse reactions

周倩、韩心雨、李艳敏、王国玲、李丽梅

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内蒙古自治区人民医院血液科,内蒙古 呼和浩特 010017

弥漫大B细胞淋巴瘤 老年 联合用药 不良反应

内蒙古自治区人民医院院内基金项目内蒙古自治区自然科学基金项目

2022YN17

2023

10.16440/J.CNKI.1674-8166.2023.11.05

慢性病学杂志

慢性病学杂志

ISSN：
年,卷(期)：2023.24(11)
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